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| 2/18 | | Southeast Missouri | @ | Dallas Baptist | 6:30 pm |
| 2/19 | | Southeast Missouri | @ | Dallas Baptist | 2 pm |
| 2/20 | | Southeast Missouri | @ | Dallas Baptist | 1 pm |
| 2/22 | | Southeast Missouri | @ | Kentucky | |
| 2/25 | | Bellarmine | @ | Southeast Missouri | |
| 2/26 | | Bellarmine | @ | Southeast Missouri | |
| 2/27 | | Bellarmine | @ | Southeast Missouri | |
| 3/1 | | Saint Louis | @ | Southeast Missouri | |
| 3/4 | | Bradley | @ | Southeast Missouri | 3 pm |
| 3/5 | | Bradley | @ | Southeast Missouri | 2 pm |
| 3/6 | | Bradley | @ | Southeast Missouri | 1 pm |
| 3/8 | | Southeast Missouri | @ | Arkansas State | |
| 3/11 | | Valparaiso | @ | Southeast Missouri | |
| 3/12 | | Valparaiso | @ | Southeast Missouri | |
| 3/13 | | Valparaiso | @ | Southeast Missouri | |
| 3/15 | | Southeast Missouri | @ | Indiana State | 3 pm |
| 3/16 | | Southeast Missouri | @ | Indiana State | 3 pm |
| 3/18 | | Southeast Missouri | @ | Missouri State | 3 pm |
| 3/19 | | Southeast Missouri | @ | Missouri State | 2 pm |
| 3/20 | | Southeast Missouri | @ | Missouri State | 1 pm |
| 3/25 | * | SIUE | @ | Southeast Missouri | |
| 3/26 | * | SIUE | @ | Southeast Missouri | |
| 3/27 | * | SIUE | @ | Southeast Missouri | |
| 3/29 | | Southeast Missouri | @ | Saint Louis | |
| 4/1 | * | Southeast Missouri | @ | Austin Peay | |
| 4/2 | * | Southeast Missouri | @ | Austin Peay | |
| 4/3 | * | Southeast Missouri | @ | Austin Peay | |
| 4/5 | | Arkansas State | @ | Southeast Missouri | |
| 4/8 | * | Murray State | @ | Southeast Missouri | |
| 4/9 | * | Murray State | @ | Southeast Missouri | |
| 4/10 | * | Murray State | @ | Southeast Missouri | |
| 4/12 | | Southern Illinois | @ | Southeast Missouri | 6 pm |
| 4/14 | * | Southeast Missouri | @ | Tennessee Tech | |
| 4/15 | * | Southeast Missouri | @ | Tennessee Tech | |
| 4/16 | * | Southeast Missouri | @ | Tennessee Tech | |
| 4/19 | | Southeast Missouri | @ | Ole Miss | 6:30 pm |
| 4/22 | * | Morehead State | @ | Southeast Missouri | |
| 4/23 | * | Morehead State | @ | Southeast Missouri | |
| 4/24 | * | Morehead State | @ | Southeast Missouri | |
| 4/26 | | Southeast Missouri | @ | Southern Illinois | 6 pm |
| 4/29 | * | Southeast Missouri | @ | Belmont | 5 pm |
| 4/30 | * | Southeast Missouri | @ | Belmont | 2 pm |
| 5/1 | * | Southeast Missouri | @ | Belmont | 1 pm |
| 5/3 | | Southeast Missouri | @ | Missouri | 6 pm |
| 5/6 | | Southeast Missouri | @ | Oklahoma State | |
| 5/7 | | Southeast Missouri | @ | Oklahoma State | |
| 5/8 | | Southeast Missouri | @ | Oklahoma State | |
| 5/10 | | Missouri State | @ | Southeast Missouri | 5 pm |
| 5/13 | * | UT Martin | @ | Southeast Missouri | |
| 5/14 | * | UT Martin | @ | Southeast Missouri | |
| 5/15 | * | UT Martin | @ | Southeast Missouri | |
| 5/19 | * | Southeast Missouri | @ | Eastern Illinois | 3 pm |
| 5/20 | * | Southeast Missouri | @ | Eastern Illinois | |
| 5/21 | * | Southeast Missouri | @ | Eastern Illinois | 1 pm |
