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| 2/18 | | SIUE | @ | Southeastern Louisiana | 11 am |
| 2/19 | | SIUE | @ | Southeastern Louisiana | |
| 2/20 | | SIUE | @ | Southeastern Louisiana | |
| 2/22 | | Saint Louis | @ | SIUE | 3 pm |
| 2/25 | | SIUE | @ | Mercer | 6 pm |
| 2/26 | | SIUE | @ | Mercer | 2 pm |
| 2/27 | | SIUE | @ | Mercer | 1 pm |
| 3/4 | | Western Michigan | @ | SIUE | 3 pm |
| 3/5 | | Western Michigan | @ | SIUE DH | 1 pm |
| 3/6 | | Western Michigan | @ | SIUE | 1 pm |
| 3/8 | | SIUE | @ | Southern Illinois | 3 pm |
| 3/11 | | Oakland | @ | SIUE | 3 pm |
| 3/12 | | Oakland | @ | SIUE | 1 pm |
| 3/13 | | Oakland | @ | SIUE | 1 pm |
| 3/16 | | Western Illinois | @ | SIUE | 4 pm |
| 3/18 | | SIUE | @ | Memphis | |
| 3/19 | | SIUE | @ | Memphis | |
| 3/20 | | SIUE | @ | Memphis | |
| 3/23 | | Evansville | @ | SIUE | 5 pm |
| 3/25 | * | SIUE | @ | Southeast Missouri | |
| 3/26 | * | SIUE | @ | Southeast Missouri | |
| 3/27 | * | SIUE | @ | Southeast Missouri | |
| 3/30 | | SIUE | @ | Missouri | 6 pm |
| 4/1 | * | UT Martin | @ | SIUE | 5 pm |
| 4/2 | * | UT Martin | @ | SIUE | 1 pm |
| 4/3 | * | UT Martin | @ | SIUE | 1 pm |
| 4/5 | | SIUE | @ | Saint Louis | 6 pm |
| 4/8 | * | SIUE | @ | Eastern Illinois | 3 pm |
| 4/9 | * | SIUE | @ | Eastern Illinois | 1 pm |
| 4/10 | * | SIUE | @ | Eastern Illinois | 1 pm |
| 4/12 | | Bradley | @ | SIUE | 5 pm |
| 4/15 | | Siena | vs. | SIUE (Carbondale, Ill.) | 2 pm |
| 4/16 | | Siena | vs. | SIUE (Carbondale, Ill.) | 12 pm |
| 4/16 | | SIUE | @ | Southern Illinois | 4 pm |
| 4/19 | | SIUE | @ | Western Illinois | 3 pm |
| 4/22 | * | Austin Peay | @ | SIUE | 5 pm |
| 4/23 | * | Austin Peay | @ | SIUE | 1 pm |
| 4/24 | * | Austin Peay | @ | SIUE | 1 pm |
| 4/26 | | Illinois State | @ | SIUE | 5 pm |
| 4/29 | * | SIUE | @ | Murray State | 5 pm |
| 4/30 | * | SIUE | @ | Murray State | 2 pm |
| 5/1 | * | SIUE | @ | Murray State | 1 pm |
| 5/6 | * | Tennessee Tech | @ | SIUE | 5 pm |
| 5/7 | * | Tennessee Tech | @ | SIUE | 1 pm |
| 5/8 | * | Tennessee Tech | @ | SIUE | 1 pm |
| 5/10 | | Southern Illinois | @ | SIUE | 5 pm |
| 5/11 | | SIUE | @ | Evansville | |
| 5/13 | * | SIUE | @ | Morehead State | 5 pm |
| 5/14 | * | SIUE | @ | Morehead State | 6 pm |
| 5/15 | * | SIUE | @ | Morehead State | 1 pm |
| 5/19 | * | Belmont | @ | SIUE | 5 pm |
| 5/20 | * | Belmont | @ | SIUE | 5 pm |
| 5/21 | * | Belmont | @ | SIUE | 1 pm |
