| 2/18 | North Alabama | @ | Southern Miss | 4 pm | |
| 2/19 | North Alabama | @ | Southern Miss | 2 pm | |
| 2/20 | North Alabama | @ | Southern Miss | 1 pm | |
| 2/22 | South Alabama | @ | Southern Miss | 6 pm | |
| 2/25 | Jacksonville State | @ | Southern Miss | 6 pm | |
| 2/26 | Jacksonville State | @ | Southern Miss | 2 pm | |
| 2/27 | Jacksonville State | @ | Southern Miss | 1 pm | |
| 3/2 | Mississippi State | vs. | Southern Miss (Pearl, Miss.) | ||
| 3/4 | Southern Miss | @ | Louisiana | 6 pm | |
| 3/5 | Southern Miss | @ | Louisiana | 2 pm | |
| 3/6 | Southern Miss | @ | Louisiana | 1 pm | |
| 3/8 | South Alabama | @ | Southern Miss | 6 pm | |
| 3/9 | Tulane | @ | Southern Miss | 6 pm | |
| 3/11 | Southern Miss | @ | Dallas Baptist | 6:30 pm | |
| 3/12 | Southern Miss | @ | Dallas Baptist | 2 pm | |
| 3/13 | Southern Miss | @ | Dallas Baptist | 1 pm | |
| 3/15 | Alabama | @ | Southern Miss | 6 pm | |
| 3/18 | * | FAU | @ | Southern Miss | 6 pm |
| 3/19 | * | FAU | @ | Southern Miss | 2 pm |
| 3/20 | * | FAU | @ | Southern Miss | 10:30 am |
| 3/22 | Southern Miss | @ | New Orleans | 6:30 pm | |
| 3/25 | * | Southern Miss | @ | WKU | 5 pm |
| 3/26 | * | Southern Miss | @ | WKU | 1 pm |
| 3/27 | * | Southern Miss | @ | WKU | 1 pm |
| 4/1 | * | Louisiana Tech | @ | Southern Miss | 6 pm |
| 4/2 | * | Louisiana Tech | @ | Southern Miss | 2 pm |
| 4/3 | * | Louisiana Tech | @ | Southern Miss | 1 pm |
| 4/5 | Ole Miss | vs. | Southern Miss (Pearl, Miss.) | ||
| 4/8 | * | Southern Miss | @ | Charlotte | 6 pm |
| 4/9 | * | Southern Miss | @ | Charlotte | 3 pm |
| 4/10 | * | Southern Miss | @ | Charlotte | 12 pm |
| 4/12 | Southeastern Louisiana | @ | Southern Miss | 6 pm | |
| 4/14 | * | Southern Miss | @ | FIU | |
| 4/15 | * | Southern Miss | @ | FIU | |
| 4/16 | * | Southern Miss | @ | FIU | |
| 4/19 | Southern Miss | @ | Tulane | 6:30 pm | |
| 4/20 | New Orleans | @ | Southern Miss | 6 pm | |
| 4/22 | * | Rice | @ | Southern Miss | 6 pm |
| 4/23 | * | Rice | @ | Southern Miss | 2 pm |
| 4/24 | * | Rice | @ | Southern Miss | 1 pm |
| 4/26 | Southern Miss | @ | Southeastern Louisiana | 6 pm | |
| 4/29 | * | Southern Miss | @ | UAB | 6 pm |
| 4/30 | * | Southern Miss | @ | UAB | 2 pm |
| 5/1 | * | Southern Miss | @ | UAB | 1 pm |
| 5/3 | South Alabama | @ | Southern Miss | 6:30 pm | |
| 5/6 | * | Old Dominion | @ | Southern Miss | 6 pm |
| 5/7 | * | Old Dominion | @ | Southern Miss | 2 pm |
| 5/8 | * | Old Dominion | @ | Southern Miss | 11:30 am |
| 5/11 | Ole Miss | @ | Southern Miss | 6 pm | |
| 5/13 | * | UTSA | @ | Southern Miss | 6 pm |
| 5/14 | * | UTSA | @ | Southern Miss | 2 pm |
| 5/15 | * | UTSA | @ | Southern Miss | 1 pm |
| 5/19 | * | Southern Miss | @ | Middle Tennessee | 6 pm |
| 5/20 | * | Southern Miss | @ | Middle Tennessee | 6 pm |
| 5/21 | * | Southern Miss | @ | Middle Tennessee | 1 pm |
