| 2/18 | Southern Illinois | @ | ULM | 6 pm | |
| 2/19 | Southern Illinois | @ | ULM | 6 pm | |
| 2/20 | Southern Illinois | @ | ULM | 1 pm | |
| 2/22 | Southern Illinois | @ | Austin Peay | 3 pm | |
| 2/25 | Southern Illinois | @ | Central Arkansas | 6 pm | |
| 2/26 | Southern Illinois | @ | Central Arkansas | 4 pm | |
| 2/27 | Southern Illinois | @ | Central Arkansas | 1 pm | |
| 3/1 | Western Illinois | @ | Southern Illinois | 3 pm | |
| 3/4 | Southern Illinois | @ | Little Rock | 3 pm | |
| 3/5 | Southern Illinois | @ | Little Rock | 2 pm | |
| 3/6 | Southern Illinois | @ | Little Rock | 1 pm | |
| 3/8 | SIUE | @ | Southern Illinois | 3 pm | |
| 3/9 | Southern Illinois | @ | Arkansas State | 5 pm | |
| 3/11 | Western Michigan | @ | Southern Illinois | 6 pm | |
| 3/12 | Western Michigan | @ | Southern Illinois | 2 pm | |
| 3/13 | Western Michigan | @ | Southern Illinois | 1 pm | |
| 3/15 | Southern Illinois | @ | UT Martin | 5 pm | |
| 3/18 | Illinois | @ | Southern Illinois | 6 pm | |
| 3/19 | Illinois | @ | Southern Illinois | 2 pm | |
| 3/20 | Illinois | @ | Southern Illinois | 1 pm | |
| 3/22 | Arkansas State | @ | Southern Illinois | 6 pm | |
| 3/25 | Northwestern | vs. | Southern Illinois (Indianapolis, Ind.) | 11 am | |
| 3/26 | Southern Illinois | @ | Butler | 12 pm | |
| 3/26 | Northwestern | vs. | Southern Illinois (Indianapolis, Ind.) | 3 pm | |
| 3/29 | UT Martin | @ | Southern Illinois | 6 pm | |
| 4/1 | * | Bradley | @ | Southern Illinois | 6 pm |
| 4/2 | * | Bradley | @ | Southern Illinois | 2 pm |
| 4/3 | * | Bradley | @ | Southern Illinois | 1 pm |
| 4/5 | Southern Illinois | @ | Murray State | 5 pm | |
| 4/8 | * | Southern Illinois | @ | Evansville | 6 pm |
| 4/9 | * | Southern Illinois | @ | Evansville | 2 pm |
| 4/10 | * | Southern Illinois | @ | Evansville | 1 pm |
| 4/12 | Southern Illinois | @ | Southeast Missouri | 6 pm | |
| 4/14 | Siena | @ | Southern Illinois | 6 pm | |
| 4/15 | Siena | @ | Southern Illinois | 6 pm | |
| 4/16 | SIUE | @ | Southern Illinois | 4 pm | |
| 4/19 | Austin Peay | @ | Southern Illinois | 6 pm | |
| 4/22 | * | Southern Illinois | @ | Dallas Baptist | 6:30 pm |
| 4/23 | * | Southern Illinois | @ | Dallas Baptist | 2 pm |
| 4/24 | * | Southern Illinois | @ | Dallas Baptist | 1 pm |
| 4/26 | Southeast Missouri | @ | Southern Illinois | 6 pm | |
| 4/29 | * | Valparaiso | @ | Southern Illinois | 6 pm |
| 4/30 | * | Valparaiso | @ | Southern Illinois | 2 pm |
| 5/1 | * | Valparaiso | @ | Southern Illinois | 1 pm |
| 5/3 | Murray State | @ | Southern Illinois | 6 pm | |
| 5/6 | * | Southern Illinois | @ | Missouri State | 11 am |
| 5/7 | * | Southern Illinois | @ | Missouri State | 11 am |
| 5/8 | * | Southern Illinois | @ | Missouri State | 11 am |
| 5/10 | Southern Illinois | @ | SIUE | 5 pm | |
| 5/13 | * | Indiana State | @ | Southern Illinois | 6 pm |
| 5/14 | * | Indiana State | @ | Southern Illinois | 2 pm |
| 5/15 | * | Indiana State | @ | Southern Illinois | 1 pm |
| 5/17 | Saint Louis | @ | Southern Illinois | 6 pm | |
| 5/19 | * | Southern Illinois | @ | Illinois State | 5 pm |
| 5/20 | * | Southern Illinois | @ | Illinois State | 3 pm |
| 5/21 | * | Southern Illinois | @ | Illinois State | 1 pm |
