| 2/15 | Xavier | @ | North Carolina | 3 pm | |
| 2/16 | Xavier | @ | North Carolina | 2 pm | |
| 2/17 | Xavier | @ | North Carolina | 1 pm | |
| 2/22 | Xavier | @ | Samford | 4 pm | |
| 2/23 | Xavier | @ | Samford | 2 pm | |
| 2/24 | Xavier | @ | Samford | 1 pm | |
| 2/26 | Xavier | @ | Louisville | 3 pm | |
| 3/1 | Xavier | @ | Lipscomb | 4 pm | |
| 3/2 | Xavier | @ | Lipscomb | 2 pm | |
| 3/3 | Xavier | @ | Lipscomb | 1 pm | |
| 3/5 | Xavier | @ | Miami (Ohio) | 5 pm | |
| 3/6 | Xavier | @ | Wright State | 3 pm | |
| 3/8 | Xavier | @ | Arizona State | 6:30 pm | |
| 3/9 | Xavier | @ | Arizona State | 6:30 pm | |
| 3/10 | Xavier | @ | Arizona State | 12:30 pm | |
| 3/12 | Xavier | @ | Arizona | 6 pm | |
| 3/13 | Xavier | @ | Grand Canyon | 6:30 pm | |
| 3/14 | Xavier | @ | Grand Canyon | 6:30 pm | |
| 3/15 | Xavier | @ | Grand Canyon | 6:30 pm | |
| 3/16 | Xavier | @ | Grand Canyon | 2 pm | |
| 3/19 | Xavier | @ | Kentucky | 6:30 pm | |
| 3/22 | Evansville | @ | Xavier | 3 pm | |
| 3/23 | Evansville | @ | Xavier | 1 pm | |
| 3/24 | Evansville | @ | Xavier | 12 pm | |
| 3/27 | Wright State | @ | Xavier | 3 pm | |
| 3/29 | Xavier | @ | Texas | ||
| 3/30 | Xavier | @ | Texas | ||
| 3/31 | Xavier | @ | Texas | ||
| 4/3 | Xavier | @ | Eastern Kentucky | 6 pm | |
| 4/5 | * | Georgetown | @ | Xavier | 3 pm |
| 4/6 | * | Georgetown | @ | Xavier | 1 pm |
| 4/7 | * | Georgetown | @ | Xavier | 12 pm |
| 4/9 | Xavier | @ | Cincinnati (Joe Nuxhall Classic) | 6:30 pm | |
| 4/10 | Xavier | vs. | tba (Joe Nuxhall Classic – Second Round) | ||
| 4/12 | * | Xavier | @ | St. John’s | 3 pm |
| 4/13 | * | Xavier | @ | St. John’s | 1 pm |
| 4/14 | * | Xavier | @ | St. John’s | 12 pm |
| 4/16 | Xavier | @ | Ohio State | 6:35 pm | |
| 4/18 | * | Butler | @ | Xavier | 3 pm |
| 4/19 | * | Butler | @ | Xavier | 3 pm |
| 4/20 | * | Butler | @ | Xavier | 1 pm |
| 4/23 | Miami (Ohio) | @ | Xavier | 3 pm | |
| 4/26 | * | Xavier | @ | Creighton | 6:30 pm |
| 4/27 | * | Xavier | @ | Creighton | 2 pm |
| 4/28 | * | Xavier | @ | Creighton | 12 pm |
| 4/30 | Miami (Ohio) | @ | Xavier | 3 pm | |
| 5/1 | Northern Kentucky | @ | Xavier | 3 pm | |
| 5/3 | * | Seton Hall | @ | Xavier | 3 pm |
| 5/4 | * | Seton Hall | @ | Xavier | 1 pm |
| 5/5 | * | Seton Hall | @ | Xavier | 12 pm |
| 5/10 | * | Xavier | @ | Villanova | 3 pm |
| 5/11 | * | Xavier | @ | Villanova | 1 pm |
| 5/12 | * | Xavier | @ | Villanova | 12 pm |
| 5/14 | Xavier | @ | Purdue | 6 pm | |
| 5/16 | Xavier | @ | Cincinnati | 6 pm | |
| 5/17 | Cincinnati | vs. | Xavier (Mason, Ohio) | 7 pm | |
| 5/18 | Cincinnati | @ | Xavier | 1 pm |
