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| 2/15 | Kansas | @ | USC Upstate | 4 pm |
| 2/16 | Kansas | @ | USC Upstate | 2 pm |
| 2/17 | Kansas | @ | USC Upstate | 1 pm |
| 2/18 | Kansas | @ | USC Upstate | 12 pm |
| 2/19 | USC Upstate | @ | Furman | 4 pm |
| 2/22 | Pittsburgh | @ | USC Upstate | 4 pm |
| 2/23 | Bucknell | @ | USC Upstate | 4 pm |
| 2/24 | USC Upstate | vs. | VCU (Spartanburg, S.C.) | 3 pm |
| 2/27 | USC Upstate | @ | Davidson | 6 pm |
| 3/1 | Ohio | @ | USC Upstate | 4 pm |
| 3/2 | Ohio | @ | USC Upstate | 2 pm |
| 3/3 | Ohio | @ | USC Upstate | 1 pm |
| 3/6 | USC Upstate | @ | Wofford | 5 pm |
| 3/8 | Rutgers | @ | USC Upstate | 4 pm |
| 3/9 | Rutgers | @ | USC Upstate | 2 pm |
| 3/10 | Rutgers | @ | USC Upstate | 12 pm |
| 3/12 | Davidson | @ | USC Upstate | 6 pm |
| 3/13 | Furman | @ | USC Upstate | 6 pm |
| 3/15 | * | USC Upstate | @ | UNC Asheville | 6 pm |
| 3/16 | * | USC Upstate | @ | UNC Asheville | 3 pm |
| 3/17 | * | USC Upstate | @ | UNC Asheville | 1 pm |
| 3/19 | Lafayette | @ | USC Upstate | 6 pm |
| 3/22 | * | High Point | @ | USC Upstate | 6 pm |
| 3/23 | * | High Point | @ | USC Upstate | 2 pm |
| 3/24 | * | High Point | @ | USC Upstate | 1 pm |
| 3/29 | * | Gardner-Webb | @ | USC Upstate | 6 pm |
| 3/30 | * | Gardner-Webb | @ | USC Upstate | 2 pm |
| 3/31 | * | Gardner-Webb | @ | USC Upstate | 1 pm |
| 4/2 | Charleston Southern | @ | USC Upstate | 6 pm |
| 4/3 | North Carolina A&T | @ | USC Upstate | 6 pm |
| 4/5 | * | USC Upstate | @ | Radford | 6 pm |
| 4/6 | * | USC Upstate | @ | Radford | 2 pm |
| 4/7 | * | USC Upstate | @ | Radford | 1 pm |
| 4/10 | USC Upstate | @ | North Carolina A&T | 5 pm |
| 4/12 | * | Presbyterian | @ | USC Upstate | 6 pm |
| 4/13 | * | Presbyterian | @ | USC Upstate | 2 pm |
| 4/14 | * | Presbyterian | @ | USC Upstate | 1 pm |
| 4/18 | * | Campbell | @ | USC Upstate | 6 pm |
| 4/19 | * | Campbell | @ | USC Upstate | 6 pm |
| 4/20 | * | Campbell | @ | USC Upstate | 1 pm |
| 4/26 | * | USC Upstate | @ | Longwood | 5 pm |
| 4/27 | * | USC Upstate | @ | Longwood | 3 pm |
| 4/28 | * | USC Upstate | @ | Longwood | 1 pm |
| 5/3 | Alabama State | @ | USC Upstate | 6 pm |
| 5/4 | Alabama State | @ | USC Upstate | 2 pm |
| 5/5 | Alabama State | @ | USC Upstate | 1 pm |
| 5/8 | Wofford | @ | USC Upstate | 6 pm |
| 5/10 | * | USC Upstate | @ | Charleston Southern | 6 pm |
| 5/11 | * | USC Upstate | @ | Charleston Southern | 4 pm |
| 5/12 | * | USC Upstate | @ | Charleston Southern | 1 pm |
| 5/14 | USC Upstate | @ | South Carolina | 7 pm |
| 5/16 | * | Winthrop | @ | USC Upstate | 6 pm |
| 5/17 | * | Winthrop | @ | USC Upstate | 6 pm |
| 5/18 | * | Winthrop | @ | USC Upstate | 1 pm |
