| 2/19 | Northwestern State | @ | Southern Miss | 4 pm | |
| 2/20 | Northwestern State | @ | Southern Miss | 2 pm | |
| 2/21 | Northwestern State | @ | Southern Miss | 1 pm | |
| 2/23 | Southern Miss | @ | South Alabama | 6:30 pm | |
| 2/26 | UConn | @ | Southern Miss | 4 pm | |
| 2/27 | UConn | @ | Southern Miss | 2 pm | |
| 2/28 | UConn | @ | Southern Miss | 11 am | |
| 3/2 | Mississippi State | vs. | Southern Miss (Pearl, Miss.) | 6 pm | |
| 3/5 | Southern Miss | @ | Jacksonville State | 6 pm | |
| 3/6 | Southern Miss | @ | Jacksonville State | 6 pm | |
| 3/7 | Southern Miss | @ | Jacksonville State | 1 pm | |
| 3/12 | UL Lafayette | @ | Southern Miss | 6 pm | |
| 3/13 | UL Lafayette | @ | Southern Miss | 2 pm | |
| 3/14 | UL Lafayette | @ | Southern Miss | 1 pm | |
| 3/16 | Southern Miss | @ | South Alabama | 6:30 pm | |
| 3/19 | Missouri State | @ | Southern Miss | 6 pm | |
| 3/20 | Missouri State | @ | Southern Miss | 2 pm | |
| 3/21 | Missouri State | @ | Southern Miss | 1 pm | |
| 3/23 | Southern Miss | @ | Alabama | ||
| 3/26 | * | Louisiana Tech | @ | Southern Miss | 6 pm |
| 3/27 | * | Louisiana Tech | @ | Southern Miss DH | 2 pm |
| 3/28 | * | Louisiana Tech | @ | Southern Miss | 1 pm |
| 4/1 | * | Southern Miss | @ | UTSA | 6 pm |
| 4/2 | * | Southern Miss | @ | UTSA DH | 2 pm |
| 4/3 | * | Southern Miss | @ | UTSA | 1 pm |
| 4/6 | Nicholls | @ | Southern Miss | ||
| 4/9 | * | UAB | @ | Southern Miss | 6 pm |
| 4/10 | * | UAB | @ | Southern Miss DH | 2 pm |
| 4/11 | * | UAB | @ | Southern Miss | 1 pm |
| 4/13 | South Alabama | @ | Southern Miss | 6 pm | |
| 4/16 | * | Southern Miss | @ | Louisiana Tech | 6 pm |
| 4/17 | * | Southern Miss | @ | Louisiana Tech DH | 2 pm |
| 4/18 | * | Southern Miss | @ | Louisiana Tech | 1 pm |
| 4/23 | * | WKU | @ | Southern Miss | 6 pm |
| 4/24 | * | WKU | @ | Southern Miss DH | 2 pm |
| 4/25 | * | WKU | @ | Southern Miss | 1 pm |
| 4/30 | * | Southern Miss | @ | Rice | 6 pm |
| 5/1 | * | Southern Miss | @ | Rice DH | 1 pm |
| 5/2 | * | Southern Miss | @ | Rice | 1 pm |
| 5/4 | Southeastern Louisiana | @ | Southern Miss | 6 pm | |
| 5/7 | * | Middle Tennessee | @ | Southern Miss | 6 pm |
| 5/8 | * | Middle Tennessee | @ | Southern Miss DH | 2 pm |
| 5/9 | * | Middle Tennessee | @ | Southern Miss | 1 pm |
| 5/14 | * | Southern Miss | @ | FAU | 5 pm |
| 5/15 | * | Southern Miss | @ | FAU DH | 2 pm |
| 5/16 | * | Southern Miss | @ | FAU | 12 pm |
