| 2/19 | | Little Rock | @ | Rice | 6 pm |
| 2/20 | | Washington | @ | Rice | 5 pm |
| 2/21 | | HBU | @ | Rice | 4 pm |
| 2/23 | | Rice | @ | Lamar | 6 pm |
| 2/26 | | Rice | @ | UL Lafayette | 6 pm |
| 2/27 | | Rice | @ | UL Lafayette | 2 pm |
| 2/28 | | Rice | @ | UL Lafayette | 1 pm |
| 3/3 | | Prairie View A&M | @ | Rice | 6:30 pm |
| 3/5 | | Rice | vs. | Sam Houston State (Minute Maid Park) | 11 am |
| 3/6 | | Rice | vs. | Texas A&M-Corpus Christi (Minute Maid) | 11 am |
| 3/7 | | Rice | vs. | Texas State (Minute Maid Park) | 7 pm |
| 3/9 | | HBU | @ | Rice | 6:30 pm |
| 3/12 | | Northern Illinois | @ | Rice | 5 pm |
| 3/13 | | Kansas State | @ | Rice | 4 pm |
| 3/14 | | Northern Illinois | @ | Rice | 10:30 am |
| 3/15 | | Kansas State | @ | Rice | 2 pm |
| 3/17 | | Rice | @ | Texas State | 6 pm |
| 3/19 | | Southern | @ | Rice | 6 pm |
| 3/20 | | Southern | @ | Rice DH | 1 pm |
| 3/21 | | Southern | @ | Rice | 1 pm |
| 3/23 | | Rice | @ | Texas A&M | 6:30 pm |
| 3/26 | * | UTSA | @ | Rice | 6 pm |
| 3/27 | * | UTSA | @ | Rice DH | 1 pm |
| 3/28 | * | UTSA | @ | Rice | 1 pm |
| 4/1 | * | Rice | @ | Middle Tennessee | 6 pm |
| 4/2 | * | Rice | @ | Middle Tennessee DH | 1 pm |
| 4/3 | * | Rice | @ | Middle Tennessee | 11 am |
| 4/9 | * | Louisiana Tech | @ | Rice | 6 pm |
| 4/10 | * | Louisiana Tech | @ | Rice DH | 1 pm |
| 4/11 | * | Louisiana Tech | @ | Rice | 1 pm |
| 4/13 | | Incarnate Word | @ | Rice | 6:30 pm |
| 4/16 | * | Rice | @ | Old Dominion | 3 pm |
| 4/17 | * | Rice | @ | Old Dominion DH | 2 pm |
| 4/18 | * | Rice | @ | Old Dominion | 10:30 am |
| 4/23 | * | Rice | @ | UTSA | 6 pm |
| 4/24 | * | Rice | @ | UTSA DH | 2 pm |
| 4/25 | * | Rice | @ | UTSA | 1 pm |
| 4/30 | * | Southern Miss | @ | Rice | 6 pm |
| 5/1 | * | Southern Miss | @ | Rice DH | 1 pm |
| 5/2 | * | Southern Miss | @ | Rice | 1 pm |
| 5/7 | * | Rice | @ | UAB | 6 pm |
| 5/8 | * | Rice | @ | UAB DH | 1 pm |
| 5/9 | * | Rice | @ | UAB | 12:30 pm |
| 5/14 | * | Charlotte | @ | Rice | 6 pm |
| 5/15 | * | Charlotte | @ | Rice DH | 1 pm |
| 5/16 | * | Charlotte | @ | Rice | 12 pm |
| 5/18 | | Rice | @ | Texas | 6:30 pm |
