| 2/18 | Xavier | @ | Alabama | 3 pm | |
| 2/19 | Xavier | @ | Alabama | 2 pm | |
| 2/20 | Xavier | @ | Alabama | 1 pm | |
| 2/22 | Xavier | @ | Louisville | 3 pm | |
| 2/24 | Oregon State | vs. | Xavier (Surprise, Ariz.) | 1 pm | |
| 2/25 | Oregon State | vs. | Xavier (Surprise, Ariz.) | 1 pm | |
| 2/26 | Oregon State | vs. | Xavier (Surprise, Ariz.) | 5 pm | |
| 3/2 | Xavier | @ | Northern Kentucky | ||
| 3/4 | Xavier | @ | USC Upstate | 3 pm | |
| 3/5 | Xavier | @ | USC Upstate | 2 pm | |
| 3/6 | Xavier | @ | USC Upstate | 1 pm | |
| 3/8 | Xavier | @ | South Carolina | 7 pm | |
| 3/9 | Xavier | @ | Winthrop | 6 pm | |
| 3/11 | Xavier | @ | Coastal Carolina | 4 pm | |
| 3/12 | Xavier | @ | Coastal Carolina DH | 1 pm | |
| 3/13 | Xavier | @ | Coastal Carolina | 1 pm | |
| 3/16 | Xavier | @ | Wright State | ||
| 3/18 | Xavier | @ | Indiana | 4 pm | |
| 3/19 | Xavier | @ | Indiana DH | 11 am | |
| 3/20 | Xavier | @ | Indiana | 1 pm | |
| 3/23 | Michigan | @ | Xavier | 3 pm | |
| 3/25 | Xavier | @ | Cincinnati | 4 pm | |
| 3/26 | Cincinnati | vs. | Xavier (Mason, Ohio) | 4 pm | |
| 3/27 | Cincinnati | @ | Xavier | 1 pm | |
| 3/29 | Xavier | @ | Cincinnati | 7 pm | |
| 4/1 | Western Carolina | @ | Xavier | 5 pm | |
| 4/2 | Western Carolina | @ | Xavier | 2 pm | |
| 4/3 | Western Carolina | @ | Xavier | 1 pm | |
| 4/5 | Xavier | vs. | TBA (Joe Nuxhall Classic, Oxford, Ohio) | 7 pm | |
| 4/8 | * | Xavier | @ | Seton Hall | |
| 4/9 | * | Xavier | @ | Seton Hall | |
| 4/10 | * | Xavier | @ | Seton Hall | |
| 4/12 | Wright State | @ | Xavier | 3 pm | |
| 4/14 | * | Villanova | @ | Xavier | 3 pm |
| 4/15 | * | Villanova | @ | Xavier | 1 pm |
| 4/16 | * | Villanova | @ | Xavier | 1 pm |
| 4/19 | Xavier | @ | Eastern Kentucky | 6 pm | |
| 4/22 | * | Xavier | @ | Georgetown | |
| 4/23 | * | Xavier | @ | Georgetown | |
| 4/24 | * | Xavier | @ | Georgetown | |
| 4/26 | Xavier | @ | Tennessee | 6:30 pm | |
| 4/29 | * | Creighton | @ | Xavier | 3 pm |
| 4/30 | * | Creighton | @ | Xavier | 1 pm |
| 5/1 | * | Creighton | @ | Xavier | 1 pm |
| 5/6 | * | Xavier | @ | Butler | 12 pm |
| 5/7 | * | Xavier | @ | Butler | 2 pm |
| 5/8 | * | Xavier | @ | Butler | 1 pm |
| 5/10 | Xavier | @ | Michigan | 6 pm | |
| 5/13 | * | Xavier | @ | UConn | 7 pm |
| 5/14 | * | Xavier | @ | UConn | 1 pm |
| 5/15 | * | Xavier | @ | UConn | 1 pm |
| 5/17 | Northern Kentucky | @ | Xavier | 3 pm | |
| 5/19 | * | St. John’s | @ | Xavier | 3 pm |
| 5/20 | * | St. John’s | @ | Xavier | 1 pm |
| 5/21 | * | St. John’s | @ | Xavier | 1 pm |
