| 2/18 | Nebraska | @ | Sam Houston | 6:30 pm | |
| 2/19 | Nebraska | @ | Sam Houston DH | 2 pm | |
| 2/20 | Nebraska | @ | Sam Houston | 1 pm | |
| 2/22 | Oklahoma State | vs. | Sam Houston (Globe Life Field, Arlington) | 6:30 pm | |
| 2/25 | Sam Houston | @ | Dallas Baptist | 6:30 pm | |
| 2/26 | Sam Houston | @ | Dallas Baptist | 2 pm | |
| 2/27 | Sam Houston | @ | Dallas Baptist | 1 pm | |
| 3/1 | Texas | @ | Sam Houston | 6:30 pm | |
| 3/4 | Texas Southern | @ | Sam Houston | 6:30 pm | |
| 3/5 | Texas Southern | @ | Sam Houston | 3 pm | |
| 3/6 | Texas Southern | @ | Sam Houston | 1 pm | |
| 3/11 | * | Tarleton | @ | Sam Houston | 6:30 pm |
| 3/12 | * | Tarleton | @ | Sam Houston | 3 pm |
| 3/13 | * | Tarleton | @ | Sam Houston | 1 pm |
| 3/15 | Baylor | @ | Sam Houston | 6:30 pm | |
| 3/16 | Sam Houston | @ | Rice | 6:30 pm | |
| 3/18 | * | Sam Houston | @ | Lamar | 6 pm |
| 3/19 | * | Sam Houston | @ | Lamar | 2 pm |
| 3/20 | * | Sam Houston | @ | Lamar | 1 pm |
| 3/22 | Houston | @ | Sam Houston | 6:30 pm | |
| 3/25 | * | Sam Houston | @ | Stephen F. Austin | |
| 3/26 | * | Sam Houston | @ | Stephen F. Austin | |
| 3/27 | * | Sam Houston | @ | Stephen F. Austin | |
| 3/29 | Texas State | @ | Sam Houston | 6:30 pm | |
| 4/1 | * | UTRGV | @ | Sam Houston | 6:30 pm |
| 4/2 | * | UTRGV | @ | Sam Houston | 3 pm |
| 4/3 | * | UTRGV | @ | Sam Houston | 1 pm |
| 4/5 | Sam Houston | @ | Houston | 6:30 pm | |
| 4/8 | * | Sam Houston | @ | Abilene Christian | 6 pm |
| 4/9 | * | Sam Houston | @ | Abilene Christian | 3 pm |
| 4/10 | * | Sam Houston | @ | Abilene Christian | 1 pm |
| 4/12 | Rice | @ | Sam Houston | 6:30 pm | |
| 4/13 | UTSA | @ | Sam Houston | 6:30 pm | |
| 4/18 | Sam Houston | @ | McNeese | 6 pm | |
| 4/19 | Sam Houston | @ | Baylor | 6:30 pm | |
| 4/22 | * | Sam Houston | @ | Tarleton | 6 pm |
| 4/23 | * | Sam Houston | @ | Tarleton | 2 pm |
| 4/24 | * | Sam Houston | @ | Tarleton | 1 pm |
| 4/26 | Sam Houston | @ | Texas A&M | 6:30 pm | |
| 4/29 | * | Lamar | @ | Sam Houston | 6:30 pm |
| 4/30 | * | Lamar | @ | Sam Houston | 3 pm |
| 5/1 | * | Lamar | @ | Sam Houston | 1 pm |
| 5/6 | * | Stephen F. Austin | @ | Sam Houston | 6:30 pm |
| 5/7 | * | Stephen F. Austin | @ | Sam Houston | 3 pm |
| 5/8 | * | Stephen F. Austin | @ | Sam Houston | 1 pm |
| 5/10 | Houston | vs. | Sam Houston (Sugar Land, Texas) | 6:30 pm | |
| 5/13 | * | Sam Houston | @ | UTRGV | 7 pm |
| 5/14 | * | Sam Houston | @ | UTRGV | 6 pm |
| 5/15 | * | Sam Houston | @ | UTRGV | 1 pm |
| 5/17 | Sam Houston | @ | Texas | 6:30 pm | |
| 5/19 | * | Abilene Christian | @ | Sam Houston | 6:30 pm |
| 5/20 | * | Abilene Christian | @ | Sam Houston | 6:30 pm |
| 5/21 | * | Abilene Christian | @ | Sam Houston | 1 pm |
