| 2/18 | | Auburn | vs. | Oklahoma (Globe Life Field, Arlington) | 11 am |
| 2/19 | | Arizona | vs. | Oklahoma (Globe Life Field, Arlington) | 7 pm |
| 2/20 | | Michigan | vs. | Oklahoma (Globe Life Field, Arlington) | 6:30 pm |
| 2/22 | | Wichita State | @ | Oklahoma | 4 pm |
| 2/25 | | Northwestern State | @ | Oklahoma | 4 pm |
| 2/26 | | Northwestern State | @ | Oklahoma | 2 pm |
| 2/27 | | Northwestern State | @ | Oklahoma | 2 pm |
| 3/4 | | LSU | vs. | Oklahoma (Minute Maid Park, Houston) | 3 pm |
| 3/5 | | Oklahoma | vs. | UCLA (Minute Maid Park, Houston) | 11 am |
| 3/6 | | Oklahoma | vs. | Tennessee (Minute Maid Park, Houston) | 11 am |
| 3/8 | | Dallas Baptist | @ | Oklahoma | 6:30 pm |
| 3/11 | | UTSA | @ | Oklahoma | 6:30 pm |
| 3/12 | | UTSA | @ | Oklahoma | 2 pm |
| 3/13 | | UTSA | @ | Oklahoma | 2 pm |
| 3/15 | | Air Force | @ | Oklahoma | 6:30 pm |
| 3/16 | | Air Force | @ | Oklahoma | 2 pm |
| 3/18 | | New Orleans | @ | Oklahoma | 6:30 pm |
| 3/19 | | New Orleans | @ | Oklahoma | 2 pm |
| 3/20 | | New Orleans | @ | Oklahoma | 2 pm |
| 3/22 | | Oklahoma | @ | Wichita State | |
| 3/25 | * | Baylor | @ | Oklahoma | 6:30 pm |
| 3/26 | * | Baylor | @ | Oklahoma | 2 pm |
| 3/27 | * | Baylor | @ | Oklahoma | 2 pm |
| 3/29 | | Oklahoma | vs. | Oklahoma State (ONEOK Field, Tulsa) | 7 pm |
| 4/1 | * | Texas | @ | Oklahoma | 6:30 pm |
| 4/2 | * | Texas | @ | Oklahoma | 2 pm |
| 4/3 | * | Texas | @ | Oklahoma | 2 pm |
| 4/5 | | Oral Roberts | @ | Oklahoma | 6:30 pm |
| 4/8 | * | Oklahoma | @ | Oklahoma State | |
| 4/9 | * | Oklahoma | @ | Oklahoma State | |
| 4/10 | * | Oklahoma | @ | Oklahoma State | |
| 4/12 | | Oklahoma | vs. | Texas Tech (Amarillo, Texas) | 6 pm |
| 4/14 | | Pacific | @ | Oklahoma | 6:30 pm |
| 4/15 | | Lamar | @ | Oklahoma | 6:30 pm |
| 4/16 | | Pacific | @ | Oklahoma | 2 pm |
| 4/19 | | Wichita State | @ | Oklahoma | 6:30 pm |
| 4/22 | * | Oklahoma | @ | Kansas | 6 pm |
| 4/23 | * | Oklahoma | @ | Kansas | 2 pm |
| 4/24 | * | Oklahoma | @ | Kansas | 1 pm |
| 4/26 | | Oklahoma | @ | Oral Roberts | 6:30 pm |
| 4/29 | * | Kansas State | @ | Oklahoma | 6:30 pm |
| 4/30 | * | Kansas State | @ | Oklahoma | 2 pm |
| 5/1 | * | Kansas State | @ | Oklahoma | 1 pm |
| 5/3 | | Oklahoma | @ | Dallas Baptist | 6:30 pm |
| 5/6 | * | Oklahoma | @ | TCU | 6 pm |
| 5/7 | * | Oklahoma | @ | TCU | 2 pm |
| 5/8 | * | Oklahoma | @ | TCU | 1 pm |
| 5/13 | * | West Virginia | @ | Oklahoma | 6:30 pm |
| 5/14 | * | West Virginia | @ | Oklahoma | 2 pm |
| 5/15 | * | West Virginia | @ | Oklahoma | 2 pm |
| 5/19 | * | Oklahoma | @ | Texas Tech | 6:30 pm |
| 5/20 | * | Oklahoma | @ | Texas Tech | 6:30 pm |
| 5/21 | * | Oklahoma | @ | Texas Tech | 2 pm |
