| 2/18 | | Manhattan | vs. | Notre Dame (DeLand, Fla.) | 7 pm |
| 2/19 | | Notre Dame | @ | Stetson | 4 pm |
| 2/20 | | Delaware | vs. | Notre Dame (DeLand, Fla.) | 11 am |
| 2/25 | | Marist | vs. | Notre Dame (Greenville, S.C.) | 4 pm |
| 2/26 | | Monmouth | vs. | Notre Dame DH (Greenville, S.C.) | 2 pm |
| 2/27 | | Marist | vs. | Notre Dame (Greenville, S.C.) | 12 pm |
| 3/4 | | Illinois | vs. | Notre Dame (US Bank Stadium, Minneapolis) | 3 pm |
| 3/5 | | Michigan State | vs. | Notre Dame (US Bank, Minneapolis) | 11 am |
| 3/6 | | Notre Dame | @ | Minnesota | 7 pm |
| 3/8 | | Notre Dame | @ | Elon | 4 pm |
| 3/11 | * | Notre Dame | @ | NC State | |
| 3/12 | * | Notre Dame | @ | NC State | 2 pm |
| 3/13 | * | Notre Dame | @ | NC State | 1 pm |
| 3/15 | | Valparaiso | @ | Notre Dame | 5 pm |
| 3/18 | * | Notre Dame | @ | Louisville | 7 pm |
| 3/19 | * | Notre Dame | @ | Louisville | 1 pm |
| 3/20 | * | Notre Dame | @ | Louisville | 1 pm |
| 3/22 | | Northwestern | @ | Notre Dame | 4 pm |
| 3/25 | * | Virginia Tech | @ | Notre Dame | 4 pm |
| 3/26 | * | Virginia Tech | @ | Notre Dame | 2 pm |
| 3/27 | * | Virginia Tech | @ | Notre Dame | 1 pm |
| 3/29 | | Northern Illinois | @ | Notre Dame | 5 pm |
| 4/1 | * | Notre Dame | @ | Florida State | 7 pm |
| 4/2 | * | Notre Dame | @ | Florida State | 2 pm |
| 4/3 | * | Notre Dame | @ | Florida State | 1 pm |
| 4/5 | | Butler | @ | Notre Dame | 5 pm |
| 4/8 | * | Clemson | @ | Notre Dame | 5 pm |
| 4/9 | * | Clemson | @ | Notre Dame | 2 pm |
| 4/10 | * | Clemson | @ | Notre Dame | 1 pm |
| 4/12 | | Michigan | @ | Notre Dame | 6:30 pm |
| 4/14 | * | Notre Dame | @ | Duke | 6 pm |
| 4/15 | * | Notre Dame | @ | Duke | 6 pm |
| 4/16 | * | Notre Dame | @ | Duke | 1 pm |
| 4/19 | | Valparaiso | @ | Notre Dame | 5 pm |
| 4/20 | | Purdue Fort Wayne | @ | Notre Dame | 5 pm |
| 4/22 | * | Wake Forest | @ | Notre Dame | 5 pm |
| 4/23 | * | Wake Forest | @ | Notre Dame | 2 pm |
| 4/24 | * | Wake Forest | @ | Notre Dame | 1 pm |
| 4/26 | | Michigan State | vs. | Notre Dame (Comerica Park, Detroit) | 6:35 pm |
| 4/29 | * | Boston College | @ | Notre Dame | 5 pm |
| 4/30 | * | Boston College | @ | Notre Dame | 2 pm |
| 5/1 | * | Boston College | @ | Notre Dame | 1 pm |
| 5/6 | | Notre Dame | @ | William & Mary | 5 pm |
| 5/7 | | Notre Dame | @ | William & Mary DH | 1 pm |
| 5/10 | | Michigan State | @ | Notre Dame | 6 pm |
| 5/13 | * | Pittsburgh | @ | Notre Dame | 6 pm |
| 5/14 | * | Pittsburgh | @ | Notre Dame | |
| 5/15 | * | Pittsburgh | @ | Notre Dame | |
| 5/17 | | Notre Dame | @ | Northwestern | 4 pm |
| 5/19 | * | Notre Dame | @ | Miami (Fla.) | 7 pm |
| 5/20 | * | Notre Dame | @ | Miami (Fla.) | 7 pm |
| 5/21 | * | Notre Dame | @ | Miami (Fla.) | 1 pm |
