| 2/18 | | Michigan State | @ | UNLV | 6 pm |
| 2/19 | | Michigan State | @ | UNLV DH | 1 pm |
| 2/20 | | Michigan State | @ | UNLV | 12 pm |
| 2/25 | | Michigan State | @ | Abilene Christian | 4 pm |
| 2/26 | | Michigan State | @ | Abilene Christian DH | 1 pm |
| 2/27 | | Michigan State | @ | Abilene Christian | 12 pm |
| 3/4 | | Kansas | vs. | Michigan State (US Bank, Minneapolis) | 11 am |
| 3/5 | | Michigan State | vs. | Notre Dame (US Bank, Minneapolis) | 11 am |
| 3/6 | | Michigan State | vs. | West Virginia (US Bank, Minneapolis) | 10 am |
| 3/9 | | Clemson | vs. | Michigan State (Greenville, S.C.) | 6 pm |
| 3/11 | | Cincinnati | vs. | Michigan State (Greenville, S.C.) | 2 pm |
| 3/12 | | Michigan State | vs. | Western Carolina (Greenville, S.C.) | 2 pm |
| 3/13 | | Kansas | vs. | Michigan State (Greenville, S.C.) | 1 pm |
| 3/18 | | Houston Baptist | @ | Michigan State | 4 pm |
| 3/19 | | Houston Baptist | @ | Michigan State | 1 pm |
| 3/20 | | Houston Baptist | @ | Michigan State | 1 pm |
| 3/23 | | IPFW | @ | Michigan State | 4 pm |
| 3/25 | * | Illinois | @ | Michigan State | 4 pm |
| 3/26 | * | Illinois | @ | Michigan State | 1 pm |
| 3/27 | * | Illinois | @ | Michigan State | 1 pm |
| 3/29 | | Bowling Green | @ | Michigan State | 4 pm |
| 3/30 | | Youngstown State | @ | Michigan State | 4 pm |
| 4/1 | | Michigan State | @ | Evansville | 6 pm |
| 4/2 | | Michigan State | @ | Evansville | 2 pm |
| 4/3 | | Michigan State | @ | Evansville | 1 pm |
| 4/6 | | Michigan State | @ | Lansing Lugnuts (exhibition) | 7 pm |
| 4/8 | * | Michigan State | @ | Ohio State | 6 pm |
| 4/9 | * | Michigan State | @ | Ohio State | 3 pm |
| 4/10 | * | Michigan State | @ | Ohio State | 1 pm |
| 4/12 | | Eastern Michigan | @ | Michigan State | 6:35 pm |
| 4/13 | | Western Michigan | @ | Michigan State | 6:35 pm |
| 4/15 | * | Michigan | @ | Michigan State | 6:35 pm |
| 4/16 | * | Michigan | @ | Michigan State | 4 pm |
| 4/17 | * | Michigan | @ | Michigan State | 1 pm |
| 4/19 | | Oakland | @ | Michigan State | 6:35 pm |
| 4/22 | * | Michigan State | @ | Northwestern | 3:30 pm |
| 4/23 | * | Michigan State | @ | Northwestern | 2 pm |
| 4/24 | * | Michigan State | @ | Northwestern | 1 pm |
| 4/26 | | Michigan State | vs. | Notre Dame (Comerica Park, Detroit) | 6:35 pm |
| 4/29 | * | Minnesota | @ | Michigan State | 6:35 pm |
| 4/30 | * | Minnesota | @ | Michigan State | 4 pm |
| 5/1 | * | Minnesota | @ | Michigan State | 1 pm |
| 5/6 | * | Michigan State | @ | Penn State | 6 pm |
| 5/7 | * | Michigan State | @ | Penn State | 1 pm |
| 5/8 | * | Michigan State | @ | Penn State | 1 pm |
| 5/10 | | Michigan State | @ | Notre Dame | 6 pm |
| 5/11 | | Michigan State | @ | Western Michigan | 4 pm |
| 5/13 | * | Iowa | @ | Michigan State | 6:35 pm |
| 5/14 | * | Iowa | @ | Michigan State | 4 pm |
| 5/15 | * | Iowa | @ | Michigan State | 1 pm |
| 5/17 | | Michigan State | @ | Michigan | 6 pm |
| 5/19 | * | Michigan State | @ | Nebraska | 6:35 pm |
| 5/20 | * | Michigan State | @ | Nebraska | 6:35 pm |
| 5/21 | * | Michigan State | @ | Nebraska | 12 pm |
