| 2/18 | | Indiana | @ | Clemson | 4 pm |
| 2/19 | | Indiana | @ | Clemson | 3 pm |
| 2/20 | | Indiana | @ | Clemson | 1 pm |
| 2/22 | | College of Charleston | @ | Clemson | 4 pm |
| 2/25 | | Hartford | @ | Clemson | 4 pm |
| 2/26 | | Hartford | @ | Clemson | 3 pm |
| 2/27 | | Hartford | @ | Clemson | 1 pm |
| 3/1 | | USC Upstate | @ | Clemson | 4 pm |
| 3/4 | | Clemson | @ | South Carolina | |
| 3/5 | | Clemson | vs. | South Carolina (Segra Park, Columbia) | 4 pm |
| 3/6 | | South Carolina | @ | Clemson | 2 pm |
| 3/8 | | ETSU | @ | Clemson | 4 pm |
| 3/9 | | Clemson | vs. | Michigan State (Greenville, S.C.) | |
| 3/11 | | Northeastern | @ | Clemson | 4 pm |
| 3/12 | | Northeastern | @ | Clemson | 3 pm |
| 3/13 | | Northeastern | @ | Clemson | 1 pm |
| 3/15 | | Georgia State | @ | Clemson | 6 pm |
| 3/18 | * | Miami (Fla.) | @ | Clemson | 6 pm |
| 3/19 | * | Miami (Fla.) | @ | Clemson | 3 pm |
| 3/20 | * | Miami (Fla.) | @ | Clemson | 1 pm |
| 3/22 | | Coastal Carolina | @ | Clemson | 6 pm |
| 3/23 | | Winthrop | @ | Clemson | 6 pm |
| 3/25 | * | Clemson | @ | Pittsburgh | |
| 3/26 | * | Clemson | @ | Pittsburgh | |
| 3/27 | * | Clemson | @ | Pittsburgh | |
| 3/29 | | Clemson | @ | Winthrop | |
| 4/1 | * | NC State | @ | Clemson | 6 pm |
| 4/2 | * | NC State | @ | Clemson | 3 pm |
| 4/3 | * | NC State | @ | Clemson | 1 pm |
| 4/5 | | Georgia | @ | Clemson | 6 pm |
| 4/8 | * | Clemson | @ | Notre Dame | |
| 4/9 | * | Clemson | @ | Notre Dame | |
| 4/10 | * | Clemson | @ | Notre Dame | |
| 4/12 | | Clemson | vs. | USC Upstate (Greenville, S.C.) | |
| 4/15 | * | Clemson | @ | Wake Forest | |
| 4/16 | * | Clemson | @ | Wake Forest | |
| 4/17 | * | Clemson | @ | Wake Forest | |
| 4/19 | | Clemson | @ | Georgia | |
| 4/22 | * | Florida State | @ | Clemson | 6 pm |
| 4/23 | * | Florida State | @ | Clemson | 3 pm |
| 4/24 | * | Florida State | @ | Clemson | 1 pm |
| 4/26 | | Presbyterian | @ | Clemson | 6 pm |
| 4/29 | * | Clemson | @ | Louisville | |
| 4/30 | * | Clemson | @ | Louisville | |
| 5/1 | * | Clemson | @ | Louisville | |
| 5/6 | * | Georgia Tech | @ | Clemson | 6 pm |
| 5/7 | * | Georgia Tech | @ | Clemson | 3 pm |
| 5/8 | * | Georgia Tech | @ | Clemson | 1 pm |
| 5/10 | | Clemson | vs. | College of Charleston (Columbia, S.C.) | |
| 5/13 | * | Clemson | @ | Virginia | |
| 5/14 | * | Clemson | @ | Virginia | |
| 5/15 | * | Clemson | @ | Virginia | |
| 5/17 | | Clemson | @ | Coastal Carolina | |
| 5/19 | * | Boston College | @ | Clemson | 6 pm |
| 5/20 | * | Boston College | @ | Clemson | 3 pm |
| 5/21 | * | Boston College | @ | Clemson | 1 pm |
