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| 2/19 | | Toledo | @ | USC Upstate | 3 pm |
| 2/20 | | Toledo | @ | USC Upstate | 2 pm |
| 2/21 | | Toledo | @ | USC Upstate | 1 pm |
| 2/26 | | USC Upstate | @ | College of Charleston | 4 pm |
| 2/27 | | USC Upstate | @ | College of Charleston | 2 pm |
| 2/28 | | USC Upstate | @ | College of Charleston | 1 pm |
| 3/5 | * | Radford | @ | USC Upstate | 4 pm |
| 3/6 | * | Radford | @ | USC Upstate DH | 1 pm |
| 3/9 | | USC Upstate | @ | Clemson | 4 pm |
| 3/12 | * | USC Upstate | @ | Campbell | 5 pm |
| 3/13 | * | USC Upstate | @ | Campbell DH | 2 pm |
| 3/16 | * | UNC Asheville | @ | USC Upstate | 4 pm |
| 3/19 | * | High Point | @ | USC Upstate | 4 pm |
| 3/20 | * | High Point | @ | USC Upstate DH | 1 pm |
| 3/23 | * | Presbyterian | @ | USC Upstate | 4 pm |
| 3/26 | * | USC Upstate | @ | Winthrop | 5 pm |
| 3/27 | * | USC Upstate | @ | Winthrop DH | 1 pm |
| 4/1 | * | USC Upstate | @ | Radford | 6 pm |
| 4/2 | * | USC Upstate | @ | Radford DH | 1 pm |
| 4/6 | | USC Upstate | @ | Georgia Tech | 6 pm |
| 4/9 | * | Gardner-Webb | @ | USC Upstate | 6 pm |
| 4/10 | * | Gardner-Webb | @ | USC Upstate DH | 2 pm |
| 4/13 | | USC Upstate | @ | Wofford | 6 pm |
| 4/16 | * | USC Upstate | @ | Charleston Southern | 6 pm |
| 4/17 | * | USC Upstate | @ | Charleston Southern DH | 1 pm |
| 4/20 | * | USC Upstate | @ | Presbyterian | 3 pm |
| 4/23 | * | Longwood | @ | USC Upstate | 6 pm |
| 4/24 | * | Longwood | @ | USC Upstate DH | 2 pm |
| 4/30 | * | Presbyterian | @ | USC Upstate | 6 pm |
| 5/1 | * | Presbyterian | @ | USC Upstate DH | 2 pm |
| 5/5 | | USC Upstate | @ | Clemson | 6 pm |
| 5/7 | * | USC Upstate | @ | High Point | 6 pm |
| 5/8 | * | USC Upstate | @ | High Point DH | 2 pm |
| 5/11 | * | USC Upstate | @ | UNC Asheville | 5 pm |
| 5/14 | * | Campbell | @ | USC Upstate | 6 pm |
| 5/15 | * | Campbell | @ | USC Upstate DH | 2 pm |
| 5/20 | * | USC Upstate | @ | UNC Asheville | 5 pm |
| 5/21 | * | USC Upstate | @ | UNC Asheville DH | 1 pm |
