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| 2/19 | | UT Martin | @ | Samford | 4 pm |
| 2/20 | | UT Martin | @ | Samford | 2 pm |
| 2/21 | | UT Martin | @ | Samford | 1 pm |
| 2/23 | | Alabama State | @ | Samford | 4 pm |
| 2/26 | | Samford | @ | Florida | 6:30 pm |
| 2/27 | | Samford | @ | Florida | 4 pm |
| 2/28 | | Samford | @ | Florida | 1 pm |
| 3/3 | | Jacksonville State | @ | Samford | 4 pm |
| 3/5 | | Toledo | @ | Samford | 4 pm |
| 3/6 | | Toledo | @ | Samford | 2 pm |
| 3/7 | | Toledo | @ | Samford | 1 pm |
| 3/9 | | Samford | @ | Troy | 6 pm |
| 3/10 | | Samford | @ | Alabama State | 6 pm |
| 3/12 | | Samford | @ | Texas A&M | 6:30 pm |
| 3/13 | | Samford | @ | Texas A&M | 2 pm |
| 3/14 | | Samford | @ | Texas A&M | 12 pm |
| 3/16 | | Samford | @ | Mississippi State | 6 pm |
| 3/19 | * | Samford | @ | UNCG DH | 2 pm |
| 3/20 | * | Samford | @ | UNCG | 1 pm |
| 3/23 | | Samford | @ | UAB | 5:30 pm |
| 3/26 | * | ETSU | @ | Samford | 4 pm |
| 3/27 | * | ETSU | @ | Samford DH | 1 pm |
| 3/30 | | Samford | @ | Jacksonville State | 6 pm |
| 4/2 | * | VMI | @ | Samford DH | 2 pm |
| 4/3 | * | VMI | @ | Samford | 1 pm |
| 4/6 | | Troy | @ | Samford | 6 pm |
| 4/9 | * | The Citadel | @ | Samford | 4 pm |
| 4/10 | * | The Citadel | @ | Samford DH | 12 pm |
| 4/13 | | Samford | @ | Alabama | 6 pm |
| 4/16 | * | Samford | @ | Western Carolina | 5 pm |
| 4/17 | * | Samford | @ | Western Carolina DH | 1 pm |
| 4/20 | | Samford | @ | Auburn | 6 pm |
| 4/23 | * | Mercer | @ | Samford | 4 pm |
| 4/24 | * | Mercer | @ | Samford DH | 1 pm |
| 4/30 | * | Samford | @ | Wofford | 5 pm |
| 5/1 | * | Samford | @ | Wofford DH | 2 pm |
| 5/4 | | Alabama | @ | Samford | 6 pm |
| 5/7 | * | Samford | @ | VMI DH | 2 pm |
| 5/8 | * | Samford | @ | VMI | 1 pm |
| 5/11 | | Auburn | @ | Samford | 6 pm |
| 5/14 | * | UNCG | @ | Samford DH | 2 pm |
| 5/15 | * | UNCG | @ | Samford | 1 pm |
| 5/18 | | UAB | @ | Samford | 2 pm |
| 5/20 | * | Samford | @ | ETSU | 5 pm |
| 5/21 | * | Samford | @ | ETSU DH | 1 pm |
