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| 2/19 | | Texas Southern | @ | Houston | 2 pm |
| 2/20 | | Texas Southern | @ | Houston | 2 pm |
| 2/21 | | Texas Southern | @ | Houston | 12 pm |
| 2/23 | | Texas A&M-Corpus Christi | @ | Houston | 3 pm |
| 2/26 | | Houston | @ | Texas A&M-Corpus Christi | 6 pm |
| 2/27 | | Houston | @ | Texas A&M-Corpus Christi | 6 pm |
| 2/28 | | Houston | @ | Texas A&M-Corpus Christi | 1 pm |
| 3/3 | | Houston | @ | Lamar | 6 pm |
| 3/5 | | Texas | @ | Houston | 6:30 pm |
| 3/6 | | Texas | @ | Houston | 2 pm |
| 3/7 | | Texas | @ | Houston | 12 pm |
| 3/10 | | Houston | @ | Incarnate Word | 6:30 pm |
| 3/12 | | Houston | @ | Texas State | 6 pm |
| 3/13 | | Houston | @ | Texas State | 2:30 pm |
| 3/14 | | Houston | @ | Texas State | 1 pm |
| 3/16 | | Texas A&M | @ | Houston | 6:30 pm |
| 3/19 | | Houston | @ | Oklahoma | 6:30 pm |
| 3/20 | | Houston | @ | Oklahoma | 2 pm |
| 3/21 | | Houston | @ | Oklahoma | 12:30 pm |
| 3/24 | | Prairie View A&M | @ | Houston DH | 2 pm |
| 3/26 | | UT Arlington | @ | Houston | 2 pm |
| 3/27 | | UT Arlington | @ | Houston | 2 pm |
| 3/28 | | UT Arlington | @ | Houston | 12 pm |
| 4/1 | * | Wichita State | @ | Houston DH | 2 pm |
| 4/2 | * | Wichita State | @ | Houston | 2 pm |
| 4/3 | * | Wichita State | @ | Houston | 11:30 am |
| 4/9 | * | Houston | @ | Wichita State DH | |
| 4/10 | * | Houston | @ | Wichita State | |
| 4/11 | * | Houston | @ | Wichita State | |
| 4/16 | * | East Carolina | @ | Houston DH | 2 pm |
| 4/17 | * | East Carolina | @ | Houston | 2 pm |
| 4/18 | * | East Carolina | @ | Houston | 11 am |
| 4/23 | * | USF | @ | Houston DH | 2 pm |
| 4/24 | * | USF | @ | Houston | 2 pm |
| 4/25 | * | USF | @ | Houston | 12 pm |
| 4/30 | * | Houston | @ | Tulane DH | |
| 5/1 | * | Houston | @ | Tulane | |
| 5/2 | * | Houston | @ | Tulane | |
| 5/7 | * | Cincinnati | @ | Houston DH | 2 pm |
| 5/8 | * | Cincinnati | @ | Houston | 2 pm |
| 5/9 | * | Cincinnati | @ | Houston | 12 pm |
| 5/14 | * | Houston | @ | Memphis DH | 1 pm |
| 5/15 | * | Houston | @ | Memphis | 2 pm |
| 5/16 | * | Houston | @ | Memphis | 12:30 pm |
| 5/20 | * | Houston | @ | UCF DH | 1 pm |
| 5/21 | * | Houston | @ | UCF | 5 pm |
| 5/22 | * | Houston | @ | UCF | 3 pm |
