| 2/15 | Purdue | @ | Southern Miss | 4 pm | |
| 2/16 | Purdue | @ | Southern Miss | 4 pm | |
| 2/17 | Purdue | @ | Southern Miss | 1 pm | |
| 2/20 | Southern Miss | vs. | Troy (Pearl, Miss.) | ||
| 2/22 | Southern Miss | @ | Mississippi State | 4 pm | |
| 2/23 | Southern Miss | @ | Mississippi State | 2 pm | |
| 2/24 | Southern Miss | @ | Mississippi State | 1 pm | |
| 2/26 | New Orleans | @ | Southern Miss | 6 pm | |
| 3/1 | Gonzaga | @ | Southern Miss | 6 pm | |
| 3/2 | Gonzaga | @ | Southern Miss | 2 pm | |
| 3/3 | Gonzaga | @ | Southern Miss | 1 pm | |
| 3/5 | Southern | @ | Southern Miss | 6 pm | |
| 3/8 | Holy Cross | @ | Southern Miss | 6 pm | |
| 3/9 | Holy Cross | @ | Southern Miss | 2 pm | |
| 3/10 | Holy Cross | @ | Southern Miss | 12 pm | |
| 3/13 | Southern Miss | @ | UL Lafayette | 6:30 pm | |
| 3/15 | * | Southern Miss | @ | Louisiana Tech | 6 pm |
| 3/16 | * | Southern Miss | @ | Louisiana Tech | 2 pm |
| 3/17 | * | Southern Miss | @ | Louisiana Tech | 1 pm |
| 3/19 | ULM | @ | Southern Miss | 6 pm | |
| 3/22 | * | Old Dominion | @ | Southern Miss | 6 pm |
| 3/23 | * | Old Dominion | @ | Southern Miss | 2 pm |
| 3/24 | * | Old Dominion | @ | Southern Miss | 1 pm |
| 3/26 | Nicholls | vs. | Southern Miss (Metairie, La.) | 6:30 pm | |
| 3/29 | * | Southern Miss | @ | UTSA | 6 pm |
| 3/30 | * | Southern Miss | @ | UTSA | 2 pm |
| 3/31 | * | Southern Miss | @ | UTSA | 1 pm |
| 4/2 | South Alabama | @ | Southern Miss | 6 pm | |
| 4/5 | * | Marshall | @ | Southern Miss | 6 pm |
| 4/6 | * | Marshall | @ | Southern Miss | 2 pm |
| 4/7 | * | Marshall | @ | Southern Miss | |
| 4/9 | Ole Miss | vs. | Southern Miss (Pearl, Miss.) | 6 pm | |
| 4/12 | * | Southern Miss | @ | FIU | |
| 4/13 | * | Southern Miss | @ | FIU | |
| 4/14 | * | Southern Miss | @ | FIU | |
| 4/16 | Southern Miss | @ | South Alabama | 6:30 pm | |
| 4/18 | * | Charlotte | @ | Southern Miss | 6 pm |
| 4/19 | * | Charlotte | @ | Southern Miss | 6 pm |
| 4/20 | * | Charlotte | @ | Southern Miss | |
| 4/23 | UL Lafayette | @ | Southern Miss | 6 pm | |
| 4/26 | * | Southern Miss | @ | Middle Tennessee | 6 pm |
| 4/27 | * | Southern Miss | @ | Middle Tennessee | 4 pm |
| 4/28 | * | Southern Miss | @ | Middle Tennessee | 1 pm |
| 5/1 | Ole Miss | @ | Southern Miss | 6 pm | |
| 5/3 | * | Florida Atlantic | @ | Southern Miss | 6 pm |
| 5/4 | * | Florida Atlantic | @ | Southern Miss | 2 pm |
| 5/5 | * | Florida Atlantic | @ | Southern Miss | 1 pm |
| 5/10 | * | Southern Miss | @ | Rice | 6:30 pm |
| 5/11 | * | Southern Miss | @ | Rice | 2 pm |
| 5/12 | * | Southern Miss | @ | Rice | 1 pm |
| 5/14 | Southeastern Louisiana | @ | Southern Miss | 6 pm | |
| 5/16 | * | UAB | @ | Southern Miss | 6 pm |
| 5/17 | * | UAB | @ | Southern Miss | 6 pm |
| 5/18 | * | UAB | @ | Southern Miss | 1 pm |
