| 2/15 | Liberty | @ | South Carolina | 4 pm |
| 2/16 | Liberty | @ | South Carolina | 3 pm |
| 2/17 | Liberty | @ | South Carolina | 1:30 pm |
| 2/19 | Winthrop | @ | South Carolina | 4 pm |
| 2/20 | Presbyterian | @ | South Carolina | 4 pm |
| 2/22 | Utah Valley | @ | South Carolina | 4 pm |
| 2/23 | Utah Valley | @ | South Carolina | 2 pm |
| 2/24 | Utah Valley | @ | South Carolina | 1:30 pm |
| 2/26 | Appalachian State | @ | South Carolina | 4 pm |
| 3/1 | South Carolina | @ | Clemson | 6 pm |
| 3/2 | Clemson | vs. | South Carolina (Greenville, S.C.) |
| 3/3 | Clemson | @ | South Carolina |
| 3/5 | The Citadel | @ | South Carolina | 7 pm |
| 3/6 | Gardner-Webb | @ | South Carolina | 7 pm |
| 3/8 | Valparaiso | @ | South Carolina | 7 pm |
| 3/9 | Valparaiso | @ | South Carolina | 4 pm |
| 3/10 | Valparaiso | @ | South Carolina | 1:30 pm |
| 3/12 | South Carolina | @ | The Citadel | 7 pm |
| 3/15 | * | Georgia | @ | South Carolina | 7 pm |
| 3/16 | * | Georgia | @ | South Carolina | 4 pm |
| 3/17 | * | Georgia | @ | South Carolina | 1:30 pm |
| 3/19 | South Carolina | @ | Furman | 6 pm |
| 3/22 | * | South Carolina | @ | Tennessee | 7 pm |
| 3/23 | * | South Carolina | @ | Tennessee | 2 pm |
| 3/24 | * | South Carolina | @ | Tennessee | 1 pm |
| 3/26 | North Carolina A&T | @ | South Carolina | 7 pm |
| 3/29 | * | Auburn | @ | South Carolina | 7 pm |
| 3/30 | * | Auburn | @ | South Carolina | 4 pm |
| 3/31 | * | Auburn | @ | South Carolina | 1:30 pm |
| 4/2 | NC State | vs. | South Carolina (BB&T Ballpark, Charlotte) | 7 pm |
| 4/5 | * | South Carolina | @ | Alabama |
| 4/6 | * | South Carolina | @ | Alabama |
| 4/7 | * | South Carolina | @ | Alabama |
| 4/9 | Charlotte | @ | South Carolina | 7 pm |
| 4/11 | * | South Carolina | @ | Florida | |
| 4/12 | * | South Carolina | @ | Florida | 6:30 pm |
| 4/13 | * | South Carolina | @ | Florida | |
| 4/16 | North Carolina | vs. | South Carolina (BB&T Ballpark, Charlotte) | 7 pm |
| 4/18 | * | Texas A&M | @ | South Carolina | 7 pm |
| 4/19 | * | Texas A&M | @ | South Carolina | 7 pm |
| 4/20 | * | Texas A&M | @ | South Carolina | 1:30 pm |
| 4/23 | Charleston Southern | @ | South Carolina | 7 pm |
| 4/26 | * | South Carolina | @ | Missouri | 6:30 pm |
| 4/27 | * | South Carolina | @ | Missouri | 6:30 pm |
| 4/28 | * | South Carolina | @ | Missouri | 2 pm |
| 5/3 | * | Vanderbilt | @ | South Carolina | 7 pm |
| 5/4 | * | Vanderbilt | @ | South Carolina | 4 pm |
| 5/5 | * | Vanderbilt | @ | South Carolina | 1:30 pm |
| 5/8 | Furman | @ | South Carolina | 7 pm |
| 5/10 | * | Kentucky | @ | South Carolina | 7 pm |
| 5/11 | * | Kentucky | @ | South Carolina | 4 pm |
| 5/12 | * | Kentucky | @ | South Carolina | 1:30 pm |
| 5/14 | USC Upstate | @ | South Carolina | 7 pm |
| 5/16 | * | South Carolina | @ | Mississippi State | 6:30 pm |
| 5/17 | * | South Carolina | @ | Mississippi State | 6:30 pm |
| 5/18 | * | South Carolina | @ | Mississippi State | 1 pm |
