| 2/15 | Michigan State | @ | New Orleans | 6:30 pm |
| 2/16 | Michigan State | @ | New Orleans | 1 pm |
| 2/17 | Michigan State | @ | New Orleans | 12 pm |
| 2/22 | Michigan State | @ | Coastal Carolina DH | 12 pm |
| 2/23 | Michigan State | vs. | NC State (Myrtle Beach, S.C.) | 11 am |
| 2/24 | Kent State | vs. | Michigan State (Conway, S.C.) | 11 am |
| 3/1 | Michigan State | @ | Arizona State | 6:30 pm |
| 3/2 | Michigan State | @ | Arizona State | 6:30 pm |
| 3/3 | Michigan State | @ | Arizona State | 12:30 pm |
| 3/5 | Michigan State | @ | Arizona | 6 pm |
| 3/8 | Michigan State | vs. | Western Carolina (Greenville, S.C.) | 1 pm |
| 3/9 | Michigan State | @ | Furman | 2 pm |
| 3/9 | Michigan State | vs. | Ohio State (Greenville, S.C.) | 6 pm |
| 3/10 | Appalachian State | vs. | Michigan State (Greenville, S.C.) | 1 pm |
| 3/15 | Michigan State | vs. | UConn (Greenville, S.C.) | 5 pm |
| 3/16 | Michigan State | vs. | UConn DH (Greenville, S.C.) | 1 pm |
| 3/17 | Michigan State | vs. | UConn (Greenville, S.C.) | 12 pm |
| 3/20 | Central Michigan | @ | Michigan State |
| 3/22 | * | Michigan State | @ | Nebraska | 6:35 pm |
| 3/23 | * | Michigan State | @ | Nebraska | 2 pm |
| 3/24 | * | Michigan State | @ | Nebraska | 1 pm |
| 3/27 | Western Michigan | @ | Michigan State |
| 3/29 | * | Michigan | @ | Michigan State | 3 pm |
| 3/30 | * | Michigan State | @ | Michigan | 2 pm |
| 3/31 | * | Michigan | @ | Michigan State | 2 pm |
| 4/2 | Michigan State | vs. | Western Michigan (Comerica Park, Detroit) | 6 pm |
| 4/5 | Indiana State | @ | Michigan State |
| 4/6 | Indiana State | @ | Michigan State |
| 4/7 | Indiana State | @ | Michigan State |
| 4/9 | Michigan State | @ | Notre Dame | 6 pm |
| 4/12 | * | Michigan State | @ | Rutgers | 2 pm |
| 4/13 | * | Michigan State | @ | Rutgers | 1 pm |
| 4/14 | * | Michigan State | @ | Rutgers | 12 pm |
| 4/17 | Eastern Michigan | @ | Michigan State |
| 4/19 | * | Indiana | @ | Michigan State |
| 4/20 | * | Indiana | @ | Michigan State |
| 4/21 | * | Indiana | @ | Michigan State |
| 4/23 | Oakland | @ | Michigan State |
| 4/24 | Toledo | @ | Michigan State |
| 4/26 | * | Northwestern | @ | Michigan State |
| 4/27 | * | Northwestern | @ | Michigan State |
| 4/28 | * | Northwestern | @ | Michigan State |
| 5/3 | * | Michigan State | @ | Purdue | 6 pm |
| 5/4 | * | Michigan State | @ | Purdue | 6 pm |
| 5/5 | * | Michigan State | @ | Purdue | 1 pm |
| 5/7 | Michigan State | @ | Michigan | 6 pm |
| 5/8 | Valparaiso | @ | Michigan State |
| 5/10 | * | Michigan State | @ | Iowa | 6 pm |
| 5/11 | * | Michigan State | @ | Iowa | 2 pm |
| 5/12 | * | Michigan State | @ | Iowa | 1 pm |
| 5/14 | Michigan State | @ | Central Michigan | 4 pm |
| 5/16 | * | Illinois | @ | Michigan State |
| 5/17 | * | Illinois | @ | Michigan State |
| 5/18 | * | Illinois | @ | Michigan State |
