| 2/15 | Northwestern State | @ | Houston | 6:30 pm |
| 2/16 | Northwestern State | @ | Houston | 6:30 pm |
| 2/17 | Northwestern State | @ | Houston | 1 pm |
| 2/19 | Houston | @ | McNeese | 6 pm |
| 2/22 | Arizona | @ | Houston | 6:30 pm |
| 2/23 | Arizona | @ | Houston | 6:30 pm |
| 2/24 | Arizona | @ | Houston | 1 pm |
| 2/26 | Houston | @ | Lamar | 6 pm |
| 3/1 | Houston | vs. | TCU (Minute Maid Park, Houston) | 3 pm |
| 3/2 | Houston | vs. | Texas State (Minute Maid Park, Houston) | 11 am |
| 3/3 | Houston | vs. | Texas A&M (Minute Maid Park, Houston) | 3 pm |
| 3/5 | Rice | @ | Houston | 6:30 pm |
| 3/8 | Army | @ | Houston | 6:30 pm |
| 3/9 | Army | @ | Houston | 6:30 pm |
| 3/10 | Army | @ | Houston | 1 pm |
| 3/12 | UTSA | @ | Houston | 6:30 pm |
| 3/15 | Houston | @ | Dallas Baptist | 6:30 pm |
| 3/16 | Houston | @ | Dallas Baptist | 2 pm |
| 3/17 | Houston | @ | Dallas Baptist | 1 pm |
| 3/19 | McNeese | @ | Houston | 6:30 pm |
| 3/22 | * | UConn | @ | Houston | 6:30 pm |
| 3/23 | * | UConn | @ | Houston | 6:30 pm |
| 3/24 | * | UConn | @ | Houston | 11:30 am |
| 3/26 | Sam Houston State | @ | Houston | 6:30 pm |
| 3/27 | Houston | @ | Stephen F. Austin | 2 pm |
| 3/29 | * | Houston | @ | Memphis | 6 pm |
| 3/30 | * | Houston | @ | Memphis | 2 pm |
| 3/31 | * | Houston | @ | Memphis | 1 pm |
| 4/3 | FIU | @ | Houston | 6:30 pm |
| 4/5 | * | East Carolina | @ | Houston | 6:30 pm |
| 4/6 | * | East Carolina | @ | Houston | 6:30 pm |
| 4/7 | * | East Carolina | @ | Houston | 1 pm |
| 4/9 | Houston | @ | Sam Houston State | 6:30 pm |
| 4/12 | * | Houston | @ | Wichita State | 6 pm |
| 4/13 | * | Houston | @ | Wichita State | 2 pm |
| 4/14 | * | Houston | @ | Wichita State |
| 4/16 | Texas A&M | @ | Houston | 6:30 pm |
| 4/18 | * | Cincinnati | @ | Houston | 6:30 pm |
| 4/19 | * | Cincinnati | @ | Houston | 6:30 pm |
| 4/20 | * | Cincinnati | @ | Houston | 1 pm |
| 4/23 | Houston | vs. | Sam Houston State (Sugar Land, Texas) | 7 pm |
| 4/26 | * | Houston | @ | USF | 7 pm |
| 4/27 | * | Houston | @ | USF | 6:30 pm |
| 4/28 | * | Houston | @ | USF | 1 pm |
| 5/3 | UNLV | @ | Houston | 6:30 pm |
| 5/4 | UNLV | @ | Houston | 6:30 pm |
| 5/5 | UNLV | @ | Houston | 1 pm |
| 5/8 | Florida Atlantic | @ | Houston | 6:30 pm |
| 5/10 | * | Tulane | @ | Houston | 6:30 pm |
| 5/11 | * | Tulane | @ | Houston | 6:30 pm |
| 5/12 | * | Tulane | @ | Houston | 1 pm |
| 5/14 | Houston | vs. | Rice (Sugar Land, Texas) | 7 pm |
| 5/16 | * | Houston | @ | UCF | 6:30 pm |
| 5/17 | * | Houston | @ | UCF | 6:30 pm |
| 5/18 | * | Houston | @ | UCF | 6:30 pm |
