| 2/15 | Lehigh | @ | Duke | 4 pm | |
| 2/16 | Lehigh | @ | Duke | 1 pm | |
| 2/17 | Lehigh | @ | Duke | 1 pm | |
| 2/19 | Duke | @ | Davidson | 6 pm | |
| 2/22 | Northwestern | @ | Duke | 4 pm | |
| 2/23 | Northwestern | @ | Duke | 1 pm | |
| 2/24 | Northwestern | @ | Duke | 1 pm | |
| 2/26 | Richmond | @ | Duke | 1 pm | |
| 3/1 | Duke | vs. | Penn State (Bradenton, Fla.) | 4 pm | |
| 3/2 | Duke | vs. | Penn State (Bradenton, Fla.) | 2 pm | |
| 3/3 | Duke | vs. | Penn State (Bradenton, Fla.) | 12 pm | |
| 3/5 | Penn | @ | Duke | 4 pm | |
| 3/6 | Penn | @ | Duke | 4 pm | |
| 3/8 | * | Duke | @ | Virginia | 4 pm |
| 3/9 | * | Duke | @ | Virginia | 1 pm |
| 3/10 | * | Duke | @ | Virginia | 1 pm |
| 3/12 | East Carolina | @ | Duke | 4 pm | |
| 3/15 | * | Louisville | @ | Duke | 4 pm |
| 3/16 | * | Louisville | @ | Duke | 1 pm |
| 3/17 | * | Louisville | @ | Duke | 1 pm |
| 3/20 | Campbell | @ | Duke | 4 pm | |
| 3/22 | * | Wake Forest | @ | Duke | 4 pm |
| 3/23 | * | Wake Forest | @ | Duke | 1 pm |
| 3/24 | * | Wake Forest | @ | Duke | 1 pm |
| 3/26 | Davidson | @ | Duke | 4 pm | |
| 3/29 | * | Duke | @ | North Carolina | 6 pm |
| 3/30 | * | Duke | @ | North Carolina | 3 pm |
| 3/31 | * | Duke | @ | North Carolina | 1 pm |
| 4/2 | Duke | vs. | Durham Bulls (exhibition) | 6 pm | |
| 4/3 | Duke | @ | East Carolina | 6 pm | |
| 4/5 | * | Pittsburgh | @ | Duke | 6 pm |
| 4/6 | * | Pittsburgh | @ | Duke | 1 pm |
| 4/7 | * | Pittsburgh | @ | Duke | 1 pm |
| 4/9 | Duke | @ | NC Central | 6 pm | |
| 4/12 | * | Virginia Tech | @ | Duke | 6 pm |
| 4/13 | * | Virginia Tech | @ | Duke | 1 pm |
| 4/14 | * | Virginia Tech | @ | Duke | 1 pm |
| 4/16 | Texas Tech | @ | Duke | 6 pm | |
| 4/19 | * | Duke | @ | Clemson | 6 pm |
| 4/20 | * | Duke | @ | Clemson | 3 pm |
| 4/21 | * | Duke | @ | Clemson | 1 pm |
| 4/23 | NC Central | @ | Duke | 6 pm | |
| 4/26 | * | Duke | @ | Boston College | 6 pm |
| 4/27 | * | Duke | @ | Boston College | 2 pm |
| 4/28 | * | Duke | @ | Boston College | 1 pm |
| 5/5 | VCU | @ | Duke DH | 12 pm | |
| 5/8 | Liberty | @ | Duke | 6 pm | |
| 5/10 | * | Georgia Tech | @ | Duke | 6 pm |
| 5/11 | * | Georgia Tech | @ | Duke | 1 pm |
| 5/12 | * | Georgia Tech | @ | Duke | 1 pm |
| 5/14 | Duke | @ | Liberty | 6 pm | |
| 5/16 | * | Duke | @ | Miami (Fla.) | 7 pm |
| 5/17 | * | Duke | @ | Miami (Fla.) | 5 pm |
| 5/18 | * | Duke | @ | Miami (Fla.) | 1 pm |
