| 2/18 | Ohio | @ | USC Upstate | 3 pm | |
| 2/19 | Ohio | @ | USC Upstate | 2 pm | |
| 2/20 | Ohio | @ | USC Upstate | 1 pm | |
| 2/23 | Western Carolina | @ | USC Upstate | 3 pm | |
| 2/25 | Manhattan | @ | USC Upstate | 3 pm | |
| 2/26 | Boston College | @ | USC Upstate | 3:30 pm | |
| 2/27 | Boston College | @ | USC Upstate | 11:30 am | |
| 2/27 | George Mason | @ | USC Upstate | 3 pm | |
| 3/1 | USC Upstate | @ | Clemson | 4 pm | |
| 3/4 | Xavier | @ | USC Upstate | 3 pm | |
| 3/5 | Xavier | @ | USC Upstate | 2 pm | |
| 3/6 | Xavier | @ | USC Upstate | 1 pm | |
| 3/9 | USC Upstate | @ | The Citadel | 5 pm | |
| 3/11 | Northern Kentucky | @ | USC Upstate | 3 pm | |
| 3/12 | Northern Kentucky | @ | USC Upstate | 2 pm | |
| 3/13 | Northern Kentucky | @ | USC Upstate | 1 pm | |
| 3/15 | USC Upstate | @ | Georgia | 5 pm | |
| 3/18 | * | USC Upstate | @ | Presbyterian | 6 pm |
| 3/19 | * | USC Upstate | @ | Presbyterian | 3 pm |
| 3/20 | * | USC Upstate | @ | Presbyterian | 1 pm |
| 3/22 | Wofford | @ | USC Upstate | 5 pm | |
| 3/25 | * | USC Upstate | @ | Radford | |
| 3/26 | * | USC Upstate | @ | Radford | |
| 3/27 | * | USC Upstate | @ | Radford | |
| 3/29 | USC Upstate | @ | Kennesaw State | 5 pm | |
| 4/1 | * | High Point | @ | USC Upstate | 6 pm |
| 4/2 | * | High Point | @ | USC Upstate | 2 pm |
| 4/3 | * | High Point | @ | USC Upstate | 1 pm |
| 4/5 | USC Upstate | @ | Georgia Tech | ||
| 4/8 | * | USC Upstate | @ | Campbell | 6 pm |
| 4/9 | * | USC Upstate | @ | Campbell | 3 pm |
| 4/10 | * | USC Upstate | @ | Campbell | 2 pm |
| 4/12 | Clemson | vs. | USC Upstate (Greenville, S.C.) | 6 pm | |
| 4/14 | * | Charleston Southern | @ | USC Upstate | 6 pm |
| 4/15 | * | Charleston Southern | @ | USC Upstate | 6 pm |
| 4/16 | * | Charleston Southern | @ | USC Upstate | 2 pm |
| 4/19 | USC Upstate | @ | Gardner-Webb | 6 pm | |
| 4/22 | * | NC A&T | @ | USC Upstate | 6 pm |
| 4/23 | * | NC A&T | @ | USC Upstate | 2 pm |
| 4/24 | * | NC A&T | @ | USC Upstate | 1 pm |
| 4/29 | * | USC Upstate | @ | Gardner-Webb | 6 pm |
| 4/30 | * | Gardner-Webb | @ | USC Upstate DH | 2 pm |
| 5/4 | USC Upstate | @ | Western Carolina | ||
| 5/6 | * | USC Upstate | @ | Longwood | |
| 5/7 | * | USC Upstate | @ | Longwood | |
| 5/8 | * | USC Upstate | @ | Longwood | |
| 5/10 | USC Upstate | @ | South Carolina | 7 pm | |
| 5/13 | * | UNC Asheville | @ | USC Upstate | 6 pm |
| 5/14 | * | UNC Asheville | @ | USC Upstate | 2 pm |
| 5/15 | * | UNC Asheville | @ | USC Upstate | 1 pm |
| 5/17 | Kennesaw State | @ | USC Upstate | 6 pm | |
| 5/19 | USC Upstate | @ | Ohio State | 6 pm | |
| 5/20 | USC Upstate | @ | Ohio State | 6 pm | |
| 5/21 | USC Upstate | @ | Ohio State | 1 pm |
