| 2/18 | | UNCG | @ | South Carolina | 4 pm |
| 2/19 | | UNCG | @ | South Carolina | 2 pm |
| 2/20 | | UNCG | @ | South Carolina | 1:30 pm |
| 2/22 | | Winthrop | @ | South Carolina | 4 pm |
| 2/25 | | George Washington | @ | South Carolina | 4 pm |
| 2/26 | | George Washington | @ | South Carolina | 2 pm |
| 2/27 | | George Washington | @ | South Carolina | 1:30 pm |
| 3/1 | | Appalachian State | vs. | South Carolina (Charlotte, N.C.) | 6 pm |
| 3/4 | | Clemson | @ | South Carolina | 7 pm |
| 3/5 | | Clemson | vs. | South Carolina (Segra Park, Columbia) | 4 pm |
| 3/6 | | South Carolina | @ | Clemson | 2 pm |
| 3/8 | | Xavier | @ | South Carolina | 7 pm |
| 3/11 | | Texas | @ | South Carolina | 7 pm |
| 3/12 | | Texas | @ | South Carolina | 4 pm |
| 3/13 | | Texas | @ | South Carolina | 1:30 pm |
| 3/15 | | Gardner-Webb | @ | South Carolina | 7 pm |
| 3/18 | * | South Carolina | @ | Tennessee | |
| 3/19 | * | South Carolina | @ | Tennessee | |
| 3/20 | * | South Carolina | @ | Tennessee | |
| 3/22 | | South Carolina | @ | The Citadel | |
| 3/24 | * | Vanderbilt | @ | South Carolina | |
| 3/25 | * | Vanderbilt | @ | South Carolina | |
| 3/26 | * | Vanderbilt | @ | South Carolina | |
| 3/29 | | Presbyterian | @ | South Carolina | 7 pm |
| 4/1 | * | South Carolina | @ | Missouri | |
| 4/2 | * | South Carolina | @ | Missouri | |
| 4/3 | * | South Carolina | @ | Missouri | |
| 4/5 | | North Carolina | vs. | South Carolina (Charlotte, N.C.) | 7 pm |
| 4/8 | * | Georgia | @ | South Carolina | |
| 4/9 | * | Georgia | @ | South Carolina | |
| 4/10 | * | Georgia | @ | South Carolina | |
| 4/12 | | North Florida | @ | South Carolina | 7 pm |
| 4/14 | * | Ole Miss | @ | South Carolina | |
| 4/15 | * | Ole Miss | @ | South Carolina | |
| 4/16 | * | Ole Miss | @ | South Carolina | |
| 4/20 | | South Carolina | @ | Winthrop | 6 pm |
| 4/22 | * | South Carolina | @ | Auburn | |
| 4/23 | * | South Carolina | @ | Auburn | |
| 4/24 | * | South Carolina | @ | Auburn | |
| 4/28 | * | Alabama | @ | South Carolina | |
| 4/29 | * | Alabama | @ | South Carolina | |
| 4/30 | * | Alabama | @ | South Carolina | |
| 5/4 | | NC A&T | @ | South Carolina | 7 pm |
| 5/6 | * | South Carolina | @ | Texas A&M | |
| 5/7 | * | South Carolina | @ | Texas A&M | |
| 5/8 | * | South Carolina | @ | Texas A&M | |
| 5/10 | | USC Upstate | @ | South Carolina | 7 pm |
| 5/13 | * | Kentucky | @ | South Carolina | |
| 5/14 | * | Kentucky | @ | South Carolina | |
| 5/15 | * | Kentucky | @ | South Carolina | |
| 5/17 | | Charlotte | @ | South Carolina | 7 pm |
| 5/19 | * | South Carolina | @ | Florida | 7 pm |
| 5/20 | * | South Carolina | @ | Florida | 2 pm |
| 5/21 | * | South Carolina | @ | Florida | |
