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| 2/18 | | Charlotte | vs. | Louisville (Tampa, Fla.) | 2 pm |
| 2/19 | | Louisville | @ | USF | 4 pm |
| 2/20 | | Louisville | vs. | UConn (Tampa, Fla.) | 9 am |
| 2/22 | | Xavier | @ | Louisville | 3 pm |
| 2/25 | | Dartmouth | @ | Louisville | 3 pm |
| 2/26 | | Dartmouth | @ | Louisville | 1 pm |
| 2/27 | | Dartmouth | @ | Louisville | 12 pm |
| 3/1 | | Morehead State | @ | Louisville | 3 pm |
| 3/4 | | Akron | @ | Louisville | 3 pm |
| 3/5 | | Akron | @ | Louisville | 1 pm |
| 3/5 | | Akron | @ | Louisville | 1 pm |
| 3/8 | | TCU | @ | Louisville | 2 pm |
| 3/11 | | Michigan | @ | Louisville | 3 pm |
| 3/12 | | Michigan | @ | Louisville | 1 pm |
| 3/13 | | Michigan | @ | Louisville | 1 pm |
| 3/15 | | Northern Kentucky | @ | Louisville | 3 pm |
| 3/16 | | Bellarmine | @ | Louisville | 11 am |
| 3/18 | * | Notre Dame | @ | Louisville | 7 pm |
| 3/19 | * | Notre Dame | @ | Louisville | 1 pm |
| 3/20 | * | Notre Dame | @ | Louisville | 1 pm |
| 3/22 | | Lipscomb | @ | Louisville | 6 pm |
| 3/25 | * | Louisville | @ | Boston College | 4 pm |
| 3/26 | * | Louisville | @ | Boston College | 2 pm |
| 3/27 | * | Louisville | @ | Boston College | 1 pm |
| 3/29 | | Louisville | @ | WKU | 5 pm |
| 4/1 | * | Louisville | @ | Pittsburgh | 3 pm |
| 4/2 | * | Louisville | @ | Pittsburgh | 3 pm |
| 4/3 | * | Louisville | @ | Pittsburgh | 1 pm |
| 4/5 | | Louisville | @ | Kentucky | 6:30 pm |
| 4/8 | * | North Carolina | @ | Louisville | 6 pm |
| 4/9 | * | North Carolina | @ | Louisville | 1 pm |
| 4/10 | * | North Carolina | @ | Louisville | 1 pm |
| 4/12 | | Cincinnati | @ | Louisville | 6 pm |
| 4/14 | * | Louisville | @ | Florida State | 7 pm |
| 4/15 | * | Louisville | @ | Florida State | 7 pm |
| 4/16 | * | Louisville | @ | Florida State | 1 pm |
| 4/19 | | Kentucky | @ | Louisville | 5 pm |
| 4/22 | * | NC State | @ | Louisville | 8 pm |
| 4/23 | * | NC State | @ | Louisville | 1 pm |
| 4/24 | * | NC State | @ | Louisville | 1 pm |
| 4/26 | | WKU | @ | Louisville | 6 pm |
| 4/29 | * | Clemson | @ | Louisville | 6 pm |
| 4/30 | * | Clemson | @ | Louisville | 1 pm |
| 5/1 | * | Clemson | @ | Louisville | 1 pm |
| 5/3 | | Louisville | @ | Vanderbilt | 6 pm |
| 5/6 | * | Louisville | @ | Wake Forest | 6 pm |
| 5/7 | * | Louisville | @ | Wake Forest | 4 pm |
| 5/8 | * | Louisville | @ | Wake Forest | 1 pm |
| 5/10 | | Indiana | @ | Louisville | 6 pm |
| 5/13 | * | Louisville | @ | Virginia Tech | 6 pm |
| 5/14 | * | Louisville | @ | Virginia Tech | 1 pm |
| 5/15 | * | Louisville | @ | Virginia Tech | 1 pm |
| 5/17 | | Eastern Kentucky | @ | Louisville | 6 pm |
| 5/19 | * | Virginia | @ | Louisville | 6 pm |
| 5/20 | * | Virginia | @ | Louisville | 6 pm |
| 5/21 | * | Virginia | @ | Louisville | 1 pm |
