| 2/18 | | California | vs. | Houston (Scottsdale, Ariz.) | 2 pm |
| 2/19 | | Houston | vs. | San Diego State (Scottsdale, Ariz.) | 6 pm |
| 2/20 | | Houston | vs. | TCU (Scottsdale, Ariz.) | 11 am |
| 2/22 | | Houston | @ | McNeese | 6 pm |
| 2/25 | | Texas Southern | @ | Houston | 6:30 pm |
| 2/26 | | UTRGV | @ | Houston | 6:30 pm |
| 2/27 | | UTRGV | @ | Houston | 6:30 pm |
| 3/1 | | Lamar | @ | Houston | 6:30 pm |
| 3/4 | | Incarnate Word | @ | Houston | 6:30 pm |
| 3/5 | | Incarnate Word | @ | Houston | 6:30 pm |
| 3/6 | | Incarnate Word | @ | Houston | 1 pm |
| 3/8 | | Houston | @ | Rice | 6:30 pm |
| 3/9 | | Southern | @ | Houston | 6:30 pm |
| 3/11 | | Houston | @ | Louisiana | 6 pm |
| 3/12 | | Houston | @ | Louisiana | 2 pm |
| 3/13 | | Houston | @ | Louisiana | 1 pm |
| 3/15 | | Houston | @ | Texas A&M | 6:30 pm |
| 3/18 | | Columbia | @ | Houston | 6:30 pm |
| 3/19 | | Columbia | @ | Houston | 6:30 pm |
| 3/20 | | Columbia | @ | Houston | 1 pm |
| 3/22 | | Houston | @ | Sam Houston | 6:30 pm |
| 3/25 | | Western Carolina | @ | Houston | 6:30 pm |
| 3/26 | | Western Carolina | @ | Houston | 6:30 pm |
| 3/27 | | Western Carolina | @ | Houston | 1 pm |
| 3/29 | | Prairie View | @ | Houston | 6:30 pm |
| 4/1 | * | Wichita State | @ | Houston | 6:30 pm |
| 4/2 | * | Wichita State | @ | Houston | 6:30 pm |
| 4/3 | * | Wichita State | @ | Houston | 1 pm |
| 4/5 | | Sam Houston | @ | Houston | 6:30 pm |
| 4/8 | * | Houston | @ | Cincinnati | 6 pm |
| 4/9 | * | Houston | @ | Cincinnati | 4 pm |
| 4/10 | * | Houston | @ | Cincinnati | 12 pm |
| 4/12 | | UTRGV | @ | Houston | 6:30 pm |
| 4/14 | * | Tulane | @ | Houston | 6:30 pm |
| 4/15 | * | Tulane | @ | Houston | 6:30 pm |
| 4/16 | * | Tulane | @ | Houston | 1 pm |
| 4/19 | | Houston Baptist | @ | Houston | 6:30 pm |
| 4/22 | * | Memphis | @ | Houston | 6:30 pm |
| 4/23 | * | Memphis | @ | Houston | 6:30 pm |
| 4/24 | * | Memphis | @ | Houston | 1 pm |
| 4/26 | | Houston | @ | Lamar | 6 pm |
| 4/29 | * | Houston | @ | USF | 6:30 pm |
| 4/30 | * | Houston | @ | USF | 2 pm |
| 5/1 | * | Houston | @ | USF | 1 pm |
| 5/4 | | Rice | @ | Houston | 6:30 pm |
| 5/6 | * | Houston | @ | Wichita State | 6 pm |
| 5/7 | * | Houston | @ | Wichita State | 2 pm |
| 5/8 | * | Houston | @ | Wichita State | 2 pm |
| 5/10 | | Houston | vs. | Sam Houston (Sugar Land, Texas) | 1 pm |
| 5/13 | * | UCF | @ | Houston | 6:30 pm |
| 5/14 | * | UCF | @ | Houston | 6:30 pm |
| 5/15 | * | UCF | @ | Houston | 1 pm |
| 5/17 | | Rice | @ | Houston | 6:30 pm |
| 5/19 | * | Houston | @ | East Carolina | 6:30 pm |
| 5/20 | * | Houston | @ | East Carolina | 6:30 pm |
| 5/21 | * | Houston | @ | East Carolina | 1 pm |
