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| 2/19 | | Bellarmine | @ | Louisville | 3 pm |
| 2/20 | | Bellarmine | @ | Louisville | 1 pm |
| 2/21 | | Bellarmine | @ | Louisville | 1 pm |
| 2/23 | | Eastern Kentucky | @ | Louisville | 3 pm |
| 2/26 | | Western Illinois | @ | Louisville | 3 pm |
| 2/27 | | Western Illinois | @ | Louisville | 1 pm |
| 2/28 | | Western Illinois | @ | Louisville | 1 pm |
| 3/6 | * | Louisville | @ | Georgia Tech | 4 pm |
| 3/7 | * | Louisville | @ | Georgia Tech | 2 pm |
| 3/8 | * | Louisville | @ | Georgia Tech | 1 pm |
| 3/9 | | Murray State | @ | Louisville | 3 pm |
| 3/12 | * | Boston College | @ | Louisville | 6 pm |
| 3/13 | * | Boston College | @ | Louisville | 1 pm |
| 3/14 | * | Boston College | @ | Louisville | 1 pm |
| 3/16 | | Louisville | @ | Eastern Kentucky | 5 pm |
| 3/19 | * | Louisville | @ | NC State | |
| 3/20 | * | Louisville | @ | NC State | |
| 3/21 | * | Louisville | @ | NC State | |
| 3/23 | | Western Kentucky | @ | Louisville | 6 pm |
| 3/26 | * | Louisville | @ | Notre Dame | |
| 3/27 | * | Louisville | @ | Notre Dame | |
| 3/28 | * | Louisville | @ | Notre Dame | |
| 3/30 | | Louisville | @ | Cincinnati | 6 pm |
| 4/2 | * | Wake Forest | @ | Louisville | 6 pm |
| 4/3 | * | Wake Forest | @ | Louisville | 1 pm |
| 4/4 | * | Wake Forest | @ | Louisville | 1 pm |
| 4/6 | | Kentucky | @ | Louisville | 6 pm |
| 4/9 | * | Florida State | @ | Louisville | 6 pm |
| 4/10 | * | Florida State | @ | Louisville | 1 pm |
| 4/11 | * | Florida State | @ | Louisville | 1 pm |
| 4/16 | * | Louisville | @ | Virginia | 6 pm |
| 4/17 | * | Louisville | @ | Virginia | 4 pm |
| 4/18 | * | Louisville | @ | Virginia | 1 pm |
| 4/20 | | Louisville | @ | Kentucky | 6:30 pm |
| 4/23 | * | Pittsburgh | @ | Louisville | 6 pm |
| 4/24 | * | Pittsburgh | @ | Louisville | 1 pm |
| 4/25 | * | Pittsburgh | @ | Louisville | 1 pm |
| 4/30 | * | Louisville | @ | Clemson | 6 pm |
| 5/1 | * | Louisville | @ | Clemson | 3 pm |
| 5/2 | * | Louisville | @ | Clemson | 12 pm |
| 5/4 | | Vanderbilt | @ | Louisville | 6 pm |
| 5/7 | * | Duke | @ | Louisville | 6 pm |
| 5/8 | * | Duke | @ | Louisville | 1 pm |
| 5/9 | * | Duke | @ | Louisville | 1 pm |
| 5/14 | * | Louisville | @ | North Carolina | 6 pm |
| 5/15 | * | Louisville | @ | North Carolina | 2 pm |
| 5/16 | * | Louisville | @ | North Carolina | 1 pm |
| 5/18 | | Morehead State | @ | Louisville | 6 pm |
| 5/20 | * | Miami (Fla.) | @ | Louisville | 6 pm |
| 5/21 | * | Miami (Fla.) | @ | Louisville | 6 pm |
| 5/22 | * | Miami (Fla.) | @ | Louisville | 1 pm |
